B Lymphoid Tyrosine Kinase (BLK) (N-Term), (AA 1-30) antibody

Details for Product No. ABIN392087
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Antigen
Synonyms MODY11, bltk, si:dkey-33i22.2, zgc:136231
Epitope
N-Term, AA 1-30
(7), (6), (6), (5), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(89), (38), (26), (1), (1), (1)
Host
Rabbit
(53), (42), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(72), (58), (37), (18), (10), (7), (7), (6), (5), (5), (4), (2), (1), (1)
Pubmed 2 references available
Catalog no. ABIN392087
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This BLK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human BLK.
Clone RB03107
Isotype Ig
Specificity This BLK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~30 amino acids from the N-terminal region of human BLK.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name BLK
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
Synonyms: B lymphoid tyrosine kinase
Molecular Weight 57607 DA
Gene ID 640
UniProt P51451
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle, Transcription Factors, Signaling, Metabolism
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-B Lymphoid Tyrosine Kinase (BLK) (N-Term), (AA 1-30) antibody Western blot analysis of anti-BLK Pab (ABIN392087) in mouse kidney tissue lysate. BLK (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
anti-B Lymphoid Tyrosine Kinase (BLK) (N-Term), (AA 1-30) antibody (2) Western blot analysis of anti-BLK Pab (ABIN392087) transiently transfected HEK-293 cell line lysate (1 µg/lane). BLK pab(arrow) was detected using the purified polyclonal antibody (1:1500 dilution).
anti-B Lymphoid Tyrosine Kinase (BLK) (N-Term), (AA 1-30) antibody (3) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Islam, Rabbani, Larsson et al.: "Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 3, pp. 1265-72, 1995 (PubMed).

Drebin, Hartzell, Griffin et al.: "Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk)." in: Oncogene, Vol. 10, Issue 3, pp. 477-86, 1995 (PubMed).

Hosts (53), (42), (2)
Reactivities (89), (38), (26), (1), (1), (1)
Applications (72), (58), (37), (18), (10), (7), (7), (6), (5), (5), (4), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (6), (6), (5), (2), (2), (1), (1), (1), (1)
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