PDX1 antibody (Pancreatic and Duodenal Homeobox 1) (AA 186-215)

Details for Product anti-PDX1 Antibody No. ABIN392141, Supplier: Log in to see
Antigen
  • ipf1
  • PDX1
  • Ad4BP
  • ELP
  • ELP-3
  • Ftz-F1
  • Ftzf1
  • SF-1
  • SF1
  • Ad4BP/SF-1
  • Ad4bp
  • Sf-1
  • GSF
  • IDX-1
  • IPF1
  • IUF1
  • MODY4
  • PDX-1
  • STF-1
  • IPF-1
  • Ipf1
  • Mody4
  • pdx-1
  • Idx1
  • Stf1
  • zgc:100874
  • XlHbox-8
  • xlhbox8
  • pancreatic and duodenal homeobox 1
  • nuclear receptor subfamily 5, group A, member 1
  • pdx1
  • PDX1
  • Nr5a1
  • Pdx1
Alternatives
anti-Human PDX1 antibody for ELISA
Epitope
AA 186-215, C-Term
40
26
19
18
13
13
6
6
6
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
236
57
41
7
6
6
5
5
4
3
2
2
2
2
2
1
1
Host
Rabbit
172
72
5
Clonality (Clone)
Polyclonal ()
Conjugate
This PDX1 antibody is un-conjugated
13
13
13
13
10
10
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
166
140
68
46
35
26
19
13
6
5
5
2
1
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen This IPF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-215 AA from the C-terminal region of human IPF.
Clone RB10579
Isotype Ig
Specificity This IPF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 193~223 amino acids from the C-terminal region of human IPF.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name IPF (PDX1 Antibody Abstract)
Background IPF is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. This nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
Synonyms: Pancreas/duodenum homeobox protein 1, PDX-1, Insulin promoter factor 1, IPF-1, Islet/duodenum homeobox-1, IDX-1, Somatostatin-transactivating factor 1, STF-1, Insulin upstream factor 1, IUF-1, Glucose-sensitive factor, GSF, PDX1, IPF1
Molecular Weight 30771 DA
Gene ID 3651
UniProt P52945
Research Area Stem Cells, Transcription Factors, Signaling, Metabolism, Cell Structure
Pathways Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Hormone Transport, Carbohydrate Homeostasis, Chromatin Binding, Maintenance of Protein Location
Application Notes WB = 1:1000, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Pancreatic and Duodenal Homeobox 1 (PDX1) (AA 186-215), (C-Term) antibody (ABIN392141) Western blot analysis of anti-IPF Antibody (C-term) (ABIN392141) in HepG2 cell line l...
Background publications Ma, Chen, Wang, Xia, Zhu, Liang, Gu, Qiao, Dai, Zou, Li, Zhang, Lan, Wong: "Pancreatic duodenal homeobox-1 (PDX1) functions as a tumor suppressor in gastric cancer." in: Carcinogenesis, Vol. 29, Issue 7, pp. 1327-33, 2008 (PubMed).

Watada, Kajimoto, Kaneto, Matsuoka, Fujitani, Miyazaki, Yamasaki: "Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription." in: Biochemical and biophysical research communications, Vol. 229, Issue 3, pp. 746-51, 1997 (PubMed).

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