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Kallikrein B, Plasma 1 (KLKB1) (Tyr629) antibody

Antigen

Kallikrein B, Plasma 1 (KLKB1)
Binding Site
Alternatives

Tyr629
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), ELISA
2 references available
Certificates ISO 9001:2008
Catalog no. ABIN392156
Quantity 0.1 mg  (0.25 mg/ml)
Price 280.50 $   Plus shipping costs $45.00
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anti-Kallikrein B, Plasma 1 (KLKB1) (Tyr629) antibody

Additional Information
Application Details Publications Images Alternatives back to top

Alternative name APS
Gene ID 10603
UniProt O14492
Immunogen This APS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 603~632 amino acids surrounding Y629 of human APS.
Isotype Ig
Description Other names: SH2B adapter protein 2, SH2 and PH domain-containing adapter protein APS, Adapter protein with pleckstrin homology and Src homology 2 domains, SH2B2, APS
Characteristics Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Specificity This APS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 603~632 amino acids surrounding Y629 of human APS.
Molecular Weight 67728 DA
Comments

Background: APS is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.

Application Details
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Application Notes The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:50~100
Concentration 0.25 mg/ml
Purification Purified
Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Restrictions For Research Use only

Publications
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Product Iseki, Kubo-Akashi, Kwon et al.: "APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation." in: Biochemical and biophysical research communications, Vol. 330, Issue 3, pp. 1005-13, 2005 (PubMed).

Katsanakis, Pillay: "Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588." in: The Journal of biological chemistry, Vol. 280, Issue 45, pp. 37827-32, 2005 (PubMed).

Alternatives
Application Details Publications Images back to top

Alternatives for antigen "Kallikrein B, Plasma 1 (KLKB1)", type "Antibodies"
Hosts Rabbit (25), Goat (1)
Reactivities Mouse (Murine) (23), Rat (Rattus) (23), Human (21), Chicken (18), Cow (Bovine) (18), Dog (Canine) (18), Horse (Equine) (18), Pig (Porcine) (18)
Applications Immunofluorescence (IF) (20), ELISA (5), Western Blotting (WB) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (3), Dot Blot (Dot) (1), Immunoelectron Microscopy (IEM) (1), Immunoprecipitation (IP) (1)
Conjugates Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), PE,Cy5.5 (2), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes pSer598 (4), Center (1), pSer346 (1), pTyr629 (1)