Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) (AA 728-757), (C-Term) antibody

Details for Product No. ABIN392176
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Antigen
Synonyms hif1a, AA959795, HIF1alpha, MOP1, bHLHe78, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, PASD8, HIF1-alpha, hif-1a
Epitope
AA 728-757, C-Term
(55), (45), (36), (20), (14), (12), (11), (11), (10), (8), (8), (8), (6), (6), (6), (6), (6), (6), (5), (5), (5), (5), (5), (5), (5), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(366), (133), (98), (61), (28), (27), (22), (14), (14), (9), (5), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(265), (179), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(41), (19), (19), (12), (12), (12), (9), (7), (7), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(329), (168), (138), (107), (107), (79), (47), (40), (31), (13), (10), (10), (9), (9), (9), (7), (4), (3), (3), (2), (2), (2), (1), (1)
Pubmed 3 references available
Quantity 400 μL
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Immunogen This HIF1Alpha antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 728-757 AA from the C-terminal region of human HIF1Alpha.
Clone RB14563
Isotype Ig
Specificity This HIF1Alpha antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 736~765 amino acids from the C-terminal region of human HIF1A.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name HIF1Alpha (HIF1A Antibody Abstract)
Background Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT).
Synonyms: Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1
Molecular Weight 92670 DA
Gene ID 3091
UniProt Q16665
Application Notes WB = 1:1000, IF = 1:10-50, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) (AA 728-757), (C-Term) antibody Western blot analysis of HIF1Alpha Antibody (C-term) (ABIN392176) in MDA-MB231 cell l...
anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) (AA 728-757), (C-Term) antibody (2) Western blot analysis of HIF1Alpha Antibody (C-term) (ABIN392176) in mouse cerebellum...
Background publications Alexandru, Graumann, Smith et al.: "UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover." in: Cell, Vol. 134, Issue 5, pp. 804-16, 2008 (PubMed).

Favaro, Nardo, Persano et al.: "Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death." in: The American journal of pathology, Vol. 173, Issue 4, pp. 1186-201, 2008 (PubMed).

Linke, Stojkoski, Kewley et al.: "Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor." in: The Journal of biological chemistry, Vol. 279, Issue 14, pp. 14391-7, 2004 (PubMed).

Validation Images
Catalog No. ABIN392176
291.50 $
Plus shipping costs $45.00
Quantity
Price
400 μL
291.50 $

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