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Details for Product No. ABIN392176

Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) (C-Term), (AA 728-757) antibody

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Antigen
Synonyms HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, hif1a, HIF1-alpha, HIF-1a, HIF1a, hif-1a
Epitope
»Alternatives C-Term, AA 728-757
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN392176
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This HIF1Alpha antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 728-757 AA from the C-terminal region of human HIF1Alpha.
Clone RB14563
Isotype Ig
Specificity This HIF1Alpha antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 736~765 amino acids from the C-terminal region of human HIF1A.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name HIF1Alpha
Background Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT).
Synonyms: Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1
Molecular Weight 92670 DA
Gene ID 3091
UniProt Q16665
Application Notes Recommend dilutions: WB : 1:1000,IF : 1:10-50,IHC : 1:10-50
Restrictions For Research Use only
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Linke, Stojkoski, Kewley et al.: "Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor." in: The Journal of biological chemistry, Vol. 279, Issue 14, pp. 14391-7, 2004 (PubMed).

Favaro, Nardo, Persano et al.: "Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death." in: The American journal of pathology, Vol. 173, Issue 4, pp. 1186-201, 2008 (PubMed).

Alexandru, Graumann, Smith et al.: "UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover." in: Cell, Vol. 134, Issue 5, pp. 804-16, 2008 (PubMed).

Alternatives for antigen "Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A)", type "Antibodies"
Hosts (178), (136), (1)
Reactivities (275), (119), (98), (78), (53), (50), (31), (28), (20), (19), (17), (4), (2), (2), (1), (1), (1), (1), (1)
Applications (256), (96), (73), (71), (57), (56), (52), (31), (19), (14), (11), (10), (9), (7), (2), (2), (1), (1)
Conjugates (33), (20), (19), (12), (12), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (36), (24), (15), (11), (8), (7), (6), (6), (6), (6), (6), (5), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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