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Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) (C-Term) antibody

Antigen

Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A)
Synonyms HIF1, MOP1, PASD8, bHLHe78, HIF-1alpha, HIF1-ALPHA, HIF1A, HIF-1a, HIF1a, hif-1a, hif1a
Binding Site
Alternatives

C-Term
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), ELISA
3 references available
Certificates ISO 9001:2008
Catalog no. ABIN392176
Quantity 0.1 mg  (0.25 mg/ml)  (Variants)
Price 280.50 $   Plus shipping costs $45.00
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anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) (C-Term) antibody

anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) (C-Term) antibody (2)

Additional Information
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Alternative name HIF1Alpha
Gene ID 3091
UniProt Q16665
Immunogen This HIF1Alpha antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 736~765 amino acids from the C-terminal region of human HIF1A.
Isotype Ig
Description Other names: Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1
Characteristics Purified Rabbit Polyclonal Antibody (Pab)
Specificity This HIF1Alpha antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 736~765 amino acids from the C-terminal region of human HIF1A.
Molecular Weight 92670 DA
Comments

Background: Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT).

Application Details
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Application Notes The suggested dilution is: ELISA ~~ 1:1,000 Immunohistochemistry ~~ 1:10~50
Concentration 0.25 mg/ml
Purification Purified
Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles
Restrictions For Research Use only

Publications
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Product Linke, Stojkoski, Kewley et al.: "Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor." in: The Journal of biological chemistry, Vol. 279, Issue 14, pp. 14391-7, 2004 (PubMed).

Favaro, Nardo, Persano et al.: "Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death." in: The American journal of pathology, Vol. 173, Issue 4, pp. 1186-201, 2008 (PubMed).

Alexandru, Graumann, Smith et al.: "UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover." in: Cell, Vol. 134, Issue 5, pp. 804-16, 2008 (PubMed).

Alternatives
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Alternatives for antigen "Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A)", type "Antibodies"
Hosts Rabbit (89), Mouse (53)
Reactivities Human (115), Mouse (Murine) (49), Rat (Rattus) (44), Cow (Bovine) (34), Chicken (23), Pig (Porcine) (22), Dog (Canine) (21), Monkey (8), Ferret (3), Sheep (Ovine) (3), Rabbit (2), Cat (Feline) (1), Hamster (1), Primates (1), Xenopus laevis (1)
Applications Western Blotting (WB) (95), ELISA (46), Immunofluorescence (IF) (42), Immunohistochemistry (IHC) (36), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (31), Immunoprecipitation (IP) (17), Immunocytochemistry (ICC) (14), Gel Shift (GS) (11), Immunohistochemistry (Frozen Sections) (IHC (fro)) (5), Electrophoretic Mobility-Shift Assay (EMSA) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Chromatin Immunoprecipitation (ChiP) (2), Immunohistochemistry (Fixed) (IHC (fx)) (2), Flow Cytometry (FACS) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates Biotin (10), FITC (3), HRP (2), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), Gold (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
Epitopes AA 432-528 (7), AA 530-826 (7), AA 329-530 (6), C-Term (5), Internal Region (5), N-Term (4), AA 400-550 (2), AA 530-825 (2), AA 609-826 (2), OH-Pro564 (2), AA 775-790 (1), Center (1), Pro564 (1)