beta-Site APP-Cleaving Enzyme 1 (BACE) (AA 38-70), (N-Term) antibody

Details for Product No. ABIN392201
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Antigen
Synonyms BACE1, MGC145931, bace2, MGC68881, MGC68482, BACE2, C76936, Bace, ASP2, BACE, HSPC104, zgc:77409
Epitope
AA 38-70, N-Term
(27), (25), (19), (12), (8), (5), (5), (5), (5), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(180), (79), (56), (6), (5), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(173), (14), (8)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(7), (6), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(126), (79), (50), (40), (20), (16), (10), (8), (8), (5), (4), (3), (2), (2), (2), (2), (1)
Pubmed 5 references available
Quantity 400 μL
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Immunogen This BACE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-70 AA from the N-terminal region of human BACE1.
Clone RB16874
Isotype Ig
Specificity This BACE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47~76 amino acids from the N-terminal region of human BACE1.
Predicted Reactivity Cow (Bovine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name BACE1 (BACE Antibody Abstract)
Background Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is BACE. This protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.
Synonyms: Beta-secretase 1 [Precursor], Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, Aspartyl protease 2, Asp 2, ASP2, Membrane-associated aspartic protease 2, Memapsin-2, BACE1, BACE
Molecular Weight 55764 DA
Gene ID 23621
UniProt P56817
Research Area Neurology, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (AA 38-70), (N-Term) antibody Western blot analysis of anti-BACE1 Antibody (N-term) (ABIN392201) in mouse heart tis...
anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (AA 38-70), (N-Term) antibody (2) Formalin-fixed and paraffin-embedded human brain tissue reacted with BACE1 antibody (...
Product cited in: Nie, Li, Yan et al.: "Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-α4β2 nAChR-APP695 cells." in: Neurochemical research, Vol. 36, Issue 5, pp. 904-12, 2011 (PubMed).

Background publications Xie, Guo: "PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein." in: The Journal of biological chemistry, Vol. 280, Issue 14, pp. 13824-32, 2005 (PubMed).

He, Li, Chang et al.: "GGA proteins mediate the recycling pathway of memapsin 2 (BACE)." in: The Journal of biological chemistry, Vol. 280, Issue 12, pp. 11696-703, 2005 (PubMed).

Chiocco, Kulnane, Younkin et al.: "Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice." in: The Journal of biological chemistry, Vol. 279, Issue 50, pp. 52535-42, 2004 (PubMed).

Huang, Chang, Koelsch et al.: "Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein." in: The Journal of biological chemistry, Vol. 279, Issue 36, pp. 37886-94, 2004 (PubMed).

Validation Images
Catalog No. ABIN392201
291.50 $
Plus shipping costs $45.00
Quantity
Price
400 μL
291.50 $

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