|+1 404 474 4654|
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Testis-Specific Kinase 2 (TESK2) (Center) antibody
|Synonyms||DGS-G, SPOGA2, STK22B, FLJ38613, MGC29168, TESK2|
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This TESK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364~393 amino acids from the center region of human TESK2.|
|Description||Other names: Testis-specific protein kinase 2, Testicular protein kinase 2|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This TESK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364~393 amino acids from the center region of human TESK2.|
|Molecular Weight||63639 DA|
Background: TESK2 is a dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. TESK2 phosphorylates cofilin at Ser-3. It may play an important role in spermatogenesis. This nuclear enzyme is thought to be activated by autophosphorylation on Ser-219. Expression is predominantly in testis and prostate, with highest concentrations in nongerminal Sertoli cells.
|Application Notes||The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500 Immunohistochemistry~~1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure|
|Restrictions||For Research Use only|
Røsok, Pedeutour, Ree et al.: "Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis." in: Genomics, Vol. 61, Issue 1, pp. 44-54, 1999 (PubMed).
Toshima, Toshima, Takeuchi et al.: "Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells." in: The Journal of biological chemistry, Vol. 276, Issue 33, pp. 31449-58, 2001 (PubMed).
Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).
|Hosts||Rabbit (6), Mouse (4)|
|Reactivities||Human (10), Mouse (Murine) (1)|
|Applications||Western Blotting (WB) (10), ELISA (9), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (5), Immunofluorescence (IF) (4), Immunocytochemistry (ICC) (1), Immunohistochemistry (IHC) (1)|
|Epitopes||Internal Region (2), Center,Cys225 (1)|