Tyrosyl-tRNA Synthetase 2, Mitochondrial (YARS2) (C-Term) antibody

Antigen: Tyrosyl-tRNA Synthetase 2, Mitochondrial (YARS2)

Synonyms: TYRRS, CGI-04, FLJ13995, mt-TyrRS, YRS, YTS, CMTDIC, AL024047, AU018965, YARS, MGC139774, MGC112837, cb204, wu:fk52b08, yars, MGC53284, yrs, yts, tyrrs, cmtdic, MGC89487, DKFZp459P229, yars2, fi41d10

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN392303

Additional Information

Characteristics: Purified Rabbit Polyclonal Antibody (Pab)

Alternative name: YARS2 (C-term)

Gene ID: 51067

Swiss-Prot: Q9Y2Z4

Immunogen: This YARS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 406~435 amino acids from the C-terminal region of human YARS2.

Isotype: Ig  (Matching secondary antibodies)

Description: Other names: Tyrosyl-tRNA synthetase, mitochondrial [Precursor], EC 6.1.1.1, Tyrosine--tRNA ligase, TyrRS, YARS2, CGI-04

Specificity: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human YARS2.

Molecular Weight: 53199 DA

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:50~100 Immunohistochemistry ~~ 1:10~50

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Metabolism, Cell Structure

Restrictions: For Research Use only

Images

Western blot analysis of anti-YARS2 Antibody (C-term) (ABIN392303) in CEM cell line lysates (35ug/lane). YARS(arrow) was detected using the purified Pab (1:60 dilution).

Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with YARS2 antibody (C-term) (ABIN392303), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. clinical relevance has not been evaluated.

Publications

Publications: Riley, Cooper, Hickey et al.: "Mutation of the mitochondrial tyrosyl-tRNA synthetase gene, YARS2, causes myopathy, lactic acidosis, and sideroblastic anemia--MLASA syndrome." in: American journal of human genetics, Vol. 87, Issue 1, pp. 52-9, 2010 (PubMed).