Aldehyde Dehydrogenase 1 Family, Member A3 (ALDH1A3) (AA 24-51), (N-Term) antibody

Details for Product No. ABIN392316
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Antigen
Synonyms RALDH3, ALDH1A3, ALDH1A6, ALDH6, MCOP8, Aldh6, V1
Epitope
AA 24-51, N-Term
(5), (5), (4), (4), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(25), (4), (1), (1), (1)
Host
Rabbit
(17), (8)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(22), (12), (9), (8), (4), (3), (2), (1), (1)
Pubmed 6 references available
Quantity 400 μL
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Immunogen This ALDH1A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-51 AA from the N-terminal region of human ALDH1A3.
Clone RB16818
Isotype Ig
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ALDH1A3 (ALDH1A3 Antibody Abstract)
Background Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme ALDH1A3 uses retinal as a substrate, either in a free or cellular retinol-binding protein form.

Synonyms: Retinaldehyde dehydrogenase 3, Aldehyde dehydrogenase 6, Aldehyde dehydrogenase family 1 member A3, ALDH1A3, ALDH6
Molecular Weight 56108 Da
Gene ID 220
UniProt P47895
Research Area Metabolism, Cell Structure
Application Notes Suggested dilutions:
WB = 1:1000, IHC (p) = 1:10-50
Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
Expiry Date 6 months
Supplier Images
anti-Aldehyde Dehydrogenase 1 Family, Member A3 (ALDH1A3) (AA 24-51), (N-Term) antibody Western blot analysis of anti-ALDH1A3 Antibody (N-term) (ABIN392316) in mouse kidney ...
anti-Aldehyde Dehydrogenase 1 Family, Member A3 (ALDH1A3) (AA 24-51), (N-Term) antibody (2) Formalin-fixed and paraffin-embedded human kideny tissue reacted with ALDH1A3 antibod...
Product cited in: Golubovskaya, OBrien, Ho et al.: "Down-regulation of ALDH1A3, CD44 or MDR1 sensitizes resistant cancer cells to FAK autophosphorylation inhibitor Y15." in: Journal of cancer research and clinical oncology, Vol. 141, Issue 9, pp. 1613-31, 2015 (PubMed).

Arnold, Kent, Hogarth et al.: "Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations." in: Journal of lipid research, Vol. 56, Issue 2, pp. 342-57, 2015 (PubMed).

Shao, Sullivan, Girard et al.: "Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 20, Issue 15, pp. 4154-66, 2014 (PubMed).

Selvam, Wong, Flanagan et al.: "Cellular level classification of breast cancer through proteomic markers using nanochannel array sensors." in: Nanomedicine (London, England), 2013 (PubMed).

Background publications Rexer, Zheng, Ong: "Retinoic acid biosynthesis by normal human breast epithelium is via aldehyde dehydrogenase 6, absent in MCF-7 cells." in: Cancer research, Vol. 61, Issue 19, pp. 7065-70, 2001 (PubMed).

Yoshida, Rzhetsky, Hsu et al.: "Human aldehyde dehydrogenase gene family." in: European journal of biochemistry / FEBS, Vol. 251, Issue 3, pp. 549-57, 1998 (PubMed).

Validation Images
Catalog No. ABIN392316
291.50 $
Plus shipping costs $45.00
Quantity
Price
400 μL
291.50 $

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