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COP9 Constitutive Photomorphogenic Homolog Subunit 3 (Arabidopsis) (COPS3) (C-Term) antibody
|Synonyms||CSN3, SGN3, MGC94156, COPS3, MGC166268, DKFZp468P1922, Csn3, Sgn3|
Alternatives Western Blotting (WB), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This COPS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 345~375 amino acids from the C-terminal region of human COPS3.|
|Description||Other names: COP9 signalosome complex subunit 3, JAB1-containing signalosome subunit 3, CSN3|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This COPS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 345~375 amino acids from the C-terminal region of human COPS3.|
|Molecular Weight||47873 DA|
Background: COPS3 possesses kinase activity that phosphorylates regulators involved in signal transduction. This protein phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.Preca|
|Research Area||Phospho-specific antibodies, Stem Cells, Cell Signaling, Protein Modifications, Cell Structure|
|Restrictions||For Research Use only|
Potocki, Chen, Lupski: "Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2." in: Genomics, Vol. 57, Issue 1, pp. 180-2, 1999 (PubMed).
Bech-Otschir, Kraft, Huang et al.: "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system." in: The EMBO journal, Vol. 20, Issue 7, pp. 1630-9, 2001 (PubMed).
Henriksen, Aagesen, Maelandsmo et al.: "Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation." in: Oncogene, Vol. 22, Issue 34, pp. 5358-61, 2003 (PubMed).
|Hosts||Rabbit (16), Goat (2), Mouse (1)|
|Reactivities||Human (19), Rat (Rattus) (6), Mouse (Murine) (4), Cow (Bovine) (2), Cat (Feline) (1), Chicken (1), Dog (Canine) (1)|
|Applications||Western Blotting (WB) (20), ELISA (16), Immunofluorescence (IF) (7), Immunohistochemistry (IHC) (6), Immunoprecipitation (IP) (3), Flow Cytometry (FACS) (2), Immunocytochemistry (ICC) (2)|
|Epitopes||C-Term (3), Internal Region (3), Center (2)|