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PI3KR1 (PI3KR1) (AA 1-30), (N-Term) antibody

Details for Product No. ABIN392570, Supplier: Log in to see
Antigen
Epitope
AA 1-30, N-Term
8
7
6
Reactivity
Human
8
Host
Rabbit
8
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
7
7
6
Supplier
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Immunogen This PI3KR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human PI3KR1.
Clone RB11634
Isotype Ig
Specificity This PI3KR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3~33 amino acids from the N-terminal region starting with leucine at position 11 of human PI3KR1.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name PI3KR1
Background Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance.
Synonyms: Phosphatidylinositol 3-kinase regulatory subunit alpha, PI3-kinase p85-subunit alpha, PtdIns-3-kinase p85-alpha, PI3K, PIK3R1, GRB1,
Molecular Weight 83598 DA
Gene ID 5295
UniProt P27986
Research Area Autophagy, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-PI3KR1 (PI3KR1) (AA 1-30), (N-Term) antibody (ABIN392570) Western blot analysis of anti-PIK3R1 Antibody (N-term L11) Pab (ABIN392570) in CEM ce...
Western Blotting (WB) image for anti-PI3KR1 (PI3KR1) (AA 1-30), (N-Term) antibody (ABIN392570) Western blot analysis of anti-PIK3R1 Antibody (N-term L11) Pab (ABIN392570) in Hela c...
Western Blotting (WB) image for anti-PI3KR1 (PI3KR1) (AA 1-30), (N-Term) antibody (ABIN392570) Western blot analysis of anti-PI3KR1 Antibody (N-term L11) Pab (ABIN392570) in 293 ce...
Product cited in: Hu, Gu, Han, Zhang, Li, Tian, Young, Yuan: "Knockdown of AGR2 induces cellular senescence in prostate cancer cells." in: Carcinogenesis, Vol. 33, Issue 6, pp. 1178-86, 2012

Background publications Kobayashi, Suzuki, Kanayama, Terao: "Genetic down-regulation of phosphoinositide 3-kinase by bikunin correlates with suppression of invasion and metastasis in human ovarian cancer HRA cells." in: The Journal of biological chemistry, Vol. 279, Issue 8, pp. 6371-9, 2004

Liu, Radisky, Wang, Bissell: "Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells." in: The Journal of cell biology, Vol. 164, Issue 4, pp. 603-12, 2004

Sun, Yang, Feldman, Sun, Bhalla, Jove, Nicosia, Cheng: "Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85alpha, androgen receptor, and Src." in: The Journal of biological chemistry, Vol. 278, Issue 44, pp. 42992-3000, 2003

Lee, Srinivas, Xia, Lu, Superty, LaPushin, Gomez-Manzano, Gal, Walsh, Force, Ueki, Mills, Kurie: "Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent Pathways cooperate to maintain lung cancer cell survival." in: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 23630-8, 2003