PIP4K2B antibody (C-Term)

Catalog No. ABIN392600

Product Details anti-PIP4K2B Antibody

Target: PIP4K2B (Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, beta (PIP4K2B))

Binding Specificity: AA 286-317, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIP4K2B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PIP5K2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-317 amino acids from the C-terminal region of human PIP5K2B.

Clone: RB1752

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-PIP4K2B antibody (ABIN392600)

Huang, Anderson, Cao, Wiechmann, Rajala: "Light-induced tyrosine phosphorylation of rod outer segment membrane proteins regulate the translocation, membrane binding and activation of type II ? phosphatidylinositol-5-phosphate 4-kinase." in: Neurochemical research, Vol. 36, Issue 4, pp. 627-35, (2011) (PubMed).

Wilcox, Hinchliffe: "Regulation of extranuclear PtdIns5P production by phosphatidylinositol phosphate 4-kinase 2alpha." in: FEBS letters, Vol. 582, Issue 9, pp. 1391-4, (2008) (PubMed).

Target Details for PIP4K2B

Target: PIP4K2B (Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, beta (PIP4K2B))

Alternative Name: PIP5K2B (PIP4K2B Products)

Background: PIP5K2B catalyzes the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. It is a member of the phosphatidylinositol-4-phosphate 5-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor.

Molecular Weight: 47378

Gene ID: 8396

NCBI Accession: NP_003550

UniProt: P78356

Pathways: Inositol Metabolic Process