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Diacylglycerol Kinase, zeta (DGKZ) (AA 989-1019), (C-Term) antibody

Details for Product No. ABIN392631, Supplier: Log in to see
Antigen
  • dgki
  • E130307B02Rik
  • ENSMUSG00000075035
  • F730209L11Rik
  • mDGK[z]
  • DAGK5
  • DAGK6
  • DGK-ZETA
  • hDGKzeta
Epitope
AA 989-1019, C-Term
18
14
6
5
5
4
2
1
1
1
1
Reactivity
Human
47
3
2
Host
Rabbit
42
4
2
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
3
3
2
2
2
2
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
32
27
23
12
8
8
2
1
1
Supplier
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Immunogen This DGKZ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 989-1019 AA from the C-terminal region of human DGKZ.
Clone RB3716
Isotype Ig
Specificity This DGKZ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 997~1026 amino acids from the C-terminal region of human DGKZ.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name DGKZ (DGKZ Antibody Abstract)
Background DGKZ belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction.
Synonyms: Diacylglycerol kinase, zeta, Diglyceride kinase, DGK-zeta, DAG kinase zeta, DAGK6
Pathways: Glycerophospholipid metabolism, Glycerolipid metabolism, Phosphatidylinositol signaling system
Molecular Weight 124122 Da
Gene ID 8525
UniProt Q13574
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:50-100, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Diacylglycerol Kinase, zeta (DGKZ) (AA 989-1019), (C-Term) antibody (ABIN392631) Western blot analysis of DGKZ (arrow) using DGKZ Antibody (C-term) (ABIN392631). 293 ...
Immunohistochemistry (IHC) image for anti-Diacylglycerol Kinase, zeta (DGKZ) (AA 989-1019), (C-Term) antibody (ABIN392631) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Immunofluorescence (IF) image for anti-Diacylglycerol Kinase, zeta (DGKZ) (AA 989-1019), (C-Term) antibody (ABIN392631) SF1 colocalizes with DGK and PA in the nuclei of H295R cells. Cells were plated onto ...
Product cited in: Li, Urs, Allegood et al.: "Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17." in: Molecular and cellular biology, Vol. 27, Issue 19, pp. 6669-85, 2007 (PubMed).

Background publications Hogan, Shepherd, Chabot et al.: "Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions." in: The Journal of biological chemistry, Vol. 276, Issue 28, pp. 26526-33, 2001 (PubMed).

Topham, Bunting, Zimmerman et al.: "Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta." in: Nature, Vol. 394, Issue 6694, pp. 697-700, 1998 (PubMed).

Ding, Bunting, Topham et al.: "Alternative splicing of the human diacylglycerol kinase zeta gene in muscle." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 11, pp. 5519-24, 1997 (PubMed).

Bunting, Tang, Zimmerman et al.: "Molecular cloning and characterization of a novel human diacylglycerol kinase zeta." in: The Journal of biological chemistry, Vol. 271, Issue 17, pp. 10230-6, 1996 (PubMed).