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Antibodies
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anti-Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) (Center,P...
Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) (Center,Phe1116) antibody
| Antigen |
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| Synonyms |
GCN2, KIAA1338, EIF2AK4 |
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Binding Site
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pThr667 (5), pThr898 (5), Internal Region (4), pThr899,Internal Region (3), AA 1-50 (1), C-Term (1), N-Term (1), N-Term,Gly11 (1), pThr325 (1), pThr899 (1)
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| Clonality |
Polyclonal |
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Host
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Reactivity
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Conjugate
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Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), PE,Cy5.5 (3), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
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Application
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 Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
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| Catalog no. |
ABIN392635 |
| Quantity |
0.1 mg (0.25 mg/ml) |
| Price |
280.50 $ Plus shipping costs $45.00
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Bulk discount
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| Shipping to |
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| Availability |
Will be delivered in 2 to 3 Business Days |
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Alternative name
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GCN2
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Gene ID
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440275
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UniProt
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Q9P2K8
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Immunogen
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This GCN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1109~1138 amino acids from the center region with phenylalanine at position 1116 of human GCN2.
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Isotype
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Ig
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Description
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Other names: Putative eIF2 alpha kinase
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Characteristics
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Purified Rabbit Polyclonal Antibody (Pab)
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Specificity
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This GCN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1109~1138 amino acids from the center region with phenylalanine at position 1116 of human GCN2.
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Molecular Weight
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186,838 DA
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Comments
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Background: EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1, MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999 [PubMed 10504407]).[supplied by OMIM]
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Application Notes
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The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500 Immunohistochemistry~~1:50~100
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Concentration
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0.25 mg/ml
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Purification
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Purified
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Buffer
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
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Storage
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Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles
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Research Area
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Translation Factors, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Signaling, Cell Structure
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Restrictions
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For Research Use only
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Product
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Blume-Jensen, Hunter: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, 2001 (PubMed).
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Alternatives for antigen "Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4)", type "Antibodies"
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Hosts
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Rabbit (46)
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Reactivities
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Human (45), Mouse (Murine) (36), Dog (Canine) (28), Horse (Equine) (28), Rat (Rattus) (28), Cow (Bovine) (10)
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Applications
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Immunofluorescence (IF) (25), ELISA (16), Western Blotting (WB) (14), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (9), Immunohistochemistry (IHC) (8), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1)
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Conjugates
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Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), PE,Cy5.5 (3), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
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Epitopes
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pThr667 (5), pThr898 (5), Internal Region (4), pThr899,Internal Region (3), AA 1-50 (1), C-Term (1), N-Term (1), N-Term,Gly11 (1), pThr325 (1), pThr899 (1)
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2013 BioMed Central Research Awards
