NUAK Family, SNF1-Like Kinase, 1 (NUAK1) (C-Term), (AA 604-634) antibody

Details for Product No. ABIN392640
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Antigen
Synonyms ARK5, AU014801, AW494241, B230104P22Rik, Omphk1
Epitope
C-Term, AA 604-634
(12), (9), (7), (3), (2), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(42), (17), (13), (12), (12), (12), (12), (4)
Host
Rabbit
(35), (4), (4)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(33), (20), (15), (10), (9), (2), (2)
Pubmed 1 reference available
Quantity 400 µL
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Catalog No. ABIN392640
291.50 $
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Immunogen This ARK5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 604-634 AA from the C-terminal region of human ARK5.
Clone RB3521
Isotype Ig
Specificity This ARK5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 612~641 amino acids from the C-terminal region of human ARK5.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ARK5
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
Synonyms: Probable serine/threonine-protein kinase KIAA0537
Molecular Weight 74000 DA
Gene ID 9891
UniProt O60285
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle, Transcription Factors, Signaling, Metabolism
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-NUAK Family, SNF1-Like Kinase, 1 (NUAK1) (C-Term), (AA 604-634) antibody Western blot analysis of anti-ARK5 Pab (ABIN392640) in mouse brain tissue lysate. ARK5 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
anti-NUAK Family, SNF1-Like Kinase, 1 (NUAK1) (C-Term), (AA 604-634) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Suzuki, Kusakai, Kishimoto et al.: "Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein." in: The Journal of biological chemistry, Vol. 278, Issue 1, pp. 48-53, 2002 (PubMed).

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