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Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) antibody

Antigen

Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB)
Synonyms
IKK2, IKKB, NFKBIKB, FLJ40509, IKK-beta, MGC131801, ikk2, ikkb, ikkbeta, MGC80376, ikk-beta, IKBKB, DIK, DLAK, DmIKK, DmIKKBeta, DmIKKb, IK, IKK, IKKbeta, Ird-5, Ird5, LRK, Lak, anon-89Bd, dIKK, dIKK- ... show more
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
5 references available
Certificates ISO 9001:2008
Catalog no. ABIN392699
Quantity 0.1 mg  (0.25 mg/ml)
Price 280.50 $   Plus shipping costs $45.00
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anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) antibody

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) antibody (2)

Additional Information
Application Details Publications Images Alternatives back to top

Alternative name IKK beta
Gene ID 3551
UniProt IKKB_HUMAN
Immunogen This IKK beta antibody is generated from rabbits immunized with recombinant human IKK beta (full length sequence).
Isotype Ig
Description Other names: Inhibitor of nuclear factor kappa B kinase beta subunit, I-kappa-B-kinase beta, IkBKB, IKK-B, I-kappa-B kinase 2, IKK2, Nuclear factor NF-kappa-B inhibitor kinase beta, NFKBIKB
Characteristics Purified Rabbit Polyclonal Antibody (Pab)
Specificity This IKK beta antibody is generated from rabbits immunized with recombinant human IKK beta (full length sequence).
Molecular Weight 86563 DA
Comments

Background: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.
Synonyms IKK2, IKKB, NFKBIKB, FLJ40509, IKK-beta, MGC131801, ikk2, ikkb, ikkbeta, MGC80376, ikk-beta, IKBKB, DIK, DLAK, DmIKK, DmIKKBeta, DmIKKb, IK, IKK, IKKbeta, Ird-5, Ird5, LRK, Lak, anon-89Bd, dIKK, dIKK-beta, ird, ird5/DmIkk[beta], DmelCG4201, CG4201

Application Details
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Application Notes The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500 Immunohistochemistry~~1:50~100
Concentration 0.25 mg/ml
Purification Purified
Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Restrictions For Research Use only

Publications
Application Details Images Alternatives back to top

Product Ebner, Bandion, Binder et al.: "GMCSF activates NF-kappaB via direct interaction of the GMCSF receptor with IkappaB kinase beta." in: Blood, Vol. 102, Issue 1, pp. 192-9, 2003 (PubMed).

Huang, Chen, Chen: "c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression." in: The Journal of biological chemistry, Vol. 278, Issue 11, pp. 9944-52, 2003 (PubMed).

Carter, Pennington, Ungurait et al.: "In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase." in: The Journal of biological chemistry, Vol. 278, Issue 22, pp. 19642-8, 2003 (PubMed).

Sakurai, Suzuki, Kawasaki et al.: "Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway." in: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36916-23, 2003 (PubMed).

Tang, Inohara, Wang et al.: "Roles for homotypic interactions and transautophosphorylation in IkappaB kinase beta IKKbeta) activation [corrected]." in: The Journal of biological chemistry, Vol. 278, Issue 40, pp. 38566-70, 2003 (PubMed).

Alternatives
Application Details Publications Images back to top

Alternatives for antigen "Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB)", type "Antibodies"
Hosts Rabbit (129), Mouse (30), Chicken (3)
Reactivities Human (166), Mouse (Murine) (76), Rat (Rattus) (76), Dog (Canine) (64), Pig (Porcine) (64), Cow (Bovine) (60), Chicken (48), Horse (Equine) (46), Rabbit (19), Cat (Feline) (1)
Applications Immunofluorescence (IF) (82), Western Blotting (WB) (76), ELISA (52), Immunohistochemistry (IHC) (23), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (20), Immunoprecipitation (IP) (19), Flow Cytometry (FACS) (8), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Immunocytochemistry (ICC) (2), Immunoelectron Microscopy (IEM) (2), Immunohistochemistry (Fixed) (IHC (fx)) (1)
Conjugates Alexa Fluor 488 (11), Alexa Fluor 350 (9), Alexa Fluor 555 (9), Alexa Fluor 647 (9), PE,Cy5.5 (8), Alexa Fluor (2), Biotin (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), FITC (2), Gold (2), HRP (2), PE (2), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1), Un-conjugated (1)
Epitopes pTyr199 (12), C-Term (10), AA 662-680 (8), pSer471 (6), pSer466 (5), pSer476 (5), pTyr188 (5), pSer733 (4), pSer740 (4), Internal Region (3), Middle Region (3), AA 310-376 (2), AA 1-175 (1), C-Term,pSer733 (1), C-Term,pSer740 (1), Center (1), Leu570 (1), N-Term (1), Ser23 (1), pSer1046 (1), pSer177, pSer181 (1), pSer376 (1), pSer474 (1), pSer731 (1)