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|+1 888 205 9894 (TF)|
Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) antibody
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|4 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Alternative name||IKK gamma|
|Immunogen||This IKK gamma antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the full length sequence of human IKK gamma.|
|Description||Other names: NF-kappaB essential modulator, NEMO, NF-kappaB essential modifier, Inhibitor of nuclear factor kappa-B kinase gamma subunit, IkB kinase gamma subunit, I-kappa-B kinase gamma, IKKG, IkB kinase-associated protein 1, IKKAP1, FIP-3|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This IKK gamma antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the full length sequence of human IKK gamma.|
|Molecular Weight||48197 DA|
Background: IKK gamma is a regulatory subunit part of the IKK-signalosome complex activation. It is also considered to be a mediator for TAX activation of NF-kappa-B. This protein could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Defects in IKBKG are the cause of anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID). EDA-ID is a X-linked recessive disorder characterized by absence of sweat glands, sparse scalp hair, rare conical teeth and immunological abnormalities resulting in severe infectious diseases. Defects in IKBKG are the cause of familial incontinentia pigmenti type II (IP2), an X-linked dominant disease causing death in male fetuses. In heterozygous female, it is characterized by disturbance of skin pigmentation sometimes associated with a variety of malformations of the eye, nails, teeth, skeleton, heart, and central nervous system.
|Synonyms||IP, IP1, IP2, FIP3, IPD2, NEMO, FIP-3, Fip3p, AMCBX1, IKK-gamma, IKK[g], AI848108, AI851264, AW124339, 1110037D23Rik, Nemo, nemo, fj33c07, wu:fj33c07, zgc:113492, MGC97885, IKBKG, IKBKG_1, IKBKG_2, DmIKK-gamma, DmIKKgamma, IKKg, IKKgamma, Kenny, Key, dIKK, dIKK-gamma, DmelCG16910, CG16910|
|Application Notes||The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500 Immunohistochemistry~~1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Neurology, Cell Structure|
|Restrictions||For Research Use only|
Chariot, Leonardi, Muller et al.: "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases." in: The Journal of biological chemistry, Vol. 277, Issue 40, pp. 37029-36, 2002 (PubMed).
Tegethoff, Behlke, Scheidereit: "Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation." in: Molecular and cellular biology, Vol. 23, Issue 6, pp. 2029-41, 2003 (PubMed).
Tang, Wang, Xiong et al.: "A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 37297-305, 2003 (PubMed).
Mauro, Vito, Mellone et al.: "Role of the adaptor protein CIKS in the activation of the IKK complex." in: Biochemical and biophysical research communications, Vol. 309, Issue 1, pp. 84-90, 2003 (PubMed).