Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) (C-Term), (AA 686-716) antibody

Details for Product No. ABIN392751
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Antigen
Epitope
C-Term, AA 686-716
(15), (15), (12), (8), (7), (6), (5), (4), (3), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(102), (41), (35), (30), (12), (12)
Host
Rabbit
(90), (21), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(80), (40), (29), (22), (20), (5), (3), (2), (2)
Pubmed 1 reference available
Quantity 400 μL
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Catalog No. ABIN392751
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Immunogen This IKK epsilon (IKKE) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 686-716 AA from the C-terminal region of human IKK epsilon (IKKE).
Clone RB3912
Isotype Ig
Specificity This IKKE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 687~716 amino acids from the C-terminal region of human IKKE.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name IKK epsilon (IKKE)
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).
Synonyms: Inhibitor of nuclear factor kappa-B kinase epsilon subunit, I kappa-B kinase epsilon, IkBKE, IKK-epsilon, IKK-E, Inducible I kappa-B kinase, IKK-i
Molecular Weight 80462 DA
Gene ID 9641
UniProt Q14164
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Metabolism, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) (C-Term), (AA 686-716) antibody The anti-IKKE Pab (ABIN392751) is used in Western blot to detect IKKE in 293 cell lysate.
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) (C-Term), (AA 686-716) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) (C-Term), (AA 686-716) antibody (3) Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with IKKE Antibody (C-term) (ABIN392751), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Blume-Jensen, Hunter: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, 2001 (PubMed).

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