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tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, beta Polypeptide (YWHAB) (C-Term), (AA 217-246) antibody

Details for Product No. ABIN392788
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Antigen
Synonyms GW128, HS1, KCIP-1, YWHAA, 1300003C17Rik, hs1, gw128, kcip-1, 14-3-3beta, 1433b, YWHAB, DKFZp459L1720
Epitope
C-Term, AA 217-246
(20), (12), (8), (7), (6), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(121), (48), (46), (14), (13), (13), (12), (5), (3), (1), (1), (1)
Host
Rabbit
(97), (31)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)
(115), (62), (34), (24), (15), (15), (10), (9), (1)
Pubmed 5 references available
Quantity 400 µL
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Catalog No. ABIN392788
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This YWHAB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-246 AA from the C-terminal region of human YWHAB.
Clone RB4064
Isotype Ig
Specificity This YWHAB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217~246 amino acids from the C-terminal region of human YWHAB.
Predicted Reactivity Cow (Bovine),Chicken,Mouse (Murine),Monkey,Rat (Rattus),Zebrafish
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name YWHAB (14-3-3 protein beta/alpha)
Background YWHAB belongs to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for the gene. Both variants encode the same protein, however, they are differentially expressed in hematopoietic cells.
Synonyms: 14-3-3 protein beta/alpha, Protein kinase C inhibitor protein-1, KCIP-1, Protein 1054
Molecular Weight 27951 DA
Gene ID 7529
UniProt P31946
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure
Application Notes IHC = 1:50-100, WB = 1:1000, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, beta Polypeptide (YWHAB) (C-Term), (AA 217-246) antibody Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
anti-tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, beta Polypeptide (YWHAB) (C-Term), (AA 217-246) antibody (2) The anti-YWHAB Pab (ABIN392788) is used in Western blot to detect YWHAB in Jurkat cell lysate.
anti-tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, beta Polypeptide (YWHAB) (C-Term), (AA 217-246) antibody (3) Western blot analysis of YWHAB (arrow) using rabbit polyclonal YWHAB Antibody (S232) (ABIN392788). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the YWHAB gene.
Background publications Shumway, Li, Xiong: "14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin." in: The Journal of biological chemistry, Vol. 278, Issue 4, pp. 2089-92, 2003 (PubMed).

Parvaresch, Yesilkaya, Baer et al.: "14-3-3 binding to the IGF-1 receptor is mediated by serine autophosphorylation." in: FEBS letters, Vol. 532, Issue 3, pp. 357-62, 2002 (PubMed).

Li, Inoki, Vacratsis et al.: "The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3." in: The Journal of biological chemistry, Vol. 278, Issue 16, pp. 13663-71, 2003 (PubMed).

Cavet, Lehoux, Berk: "14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity." in: The Journal of biological chemistry, Vol. 278, Issue 20, pp. 18376-83, 2003 (PubMed).

Komori, Ishizawa, Arai et al.: "Immunoexpression of 14-3-3 proteins in glial cytoplasmic inclusions of multiple system atrophy." in: Acta neuropathologica, Vol. 106, Issue 1, pp. 66-70, 2003 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN392788
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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