Adenylate Kinase 1 (AK1) (C-Term), (AA 165-194) antibody

Details for Product No. ABIN392795
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Antigen
Epitope
C-Term, AA 165-194
(12), (7), (7), (4), (3), (3), (2), (1), (1), (1)
Reactivity
Human, Hamster
(86), (30), (28), (22), (14), (14), (14), (12), (5), (2), (2), (1), (1)
Host
Rabbit
(68), (27), (6)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(7), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(80), (49), (33), (17), (11), (10), (9), (8), (5), (4), (2), (2), (2), (2), (1)
Pubmed 5 references available
Quantity 400 μL
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Catalog No. ABIN392795
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Immunogen This AK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-194 AA from the C-terminal region of human AK1.
Clone RB4082
Isotype Ig
Specificity This AK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165~194 amino acids from the C-terminal region of human AK1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name AK1
Background Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme.
Synonyms: Adenylate kinase isoenzyme 1, ATP-AMP transphosphorylase, AK1, Myokinase
Molecular Weight 21635 DA
Gene ID 203
UniProt P00568
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Adenylate Kinase 1 (AK1) (C-Term), (AA 165-194) antibody The anti-AK1 Pab (ABIN392795) is used in Western blot to detect AK1 in CHO cell lysate.
anti-Adenylate Kinase 1 (AK1) (C-Term), (AA 165-194) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Zuffardi, Caiulo, Maraschio et al.: "Regional assignment of the loci for adenylate kinase to 9q32 and for alpha 1-acid glycoprotein to 9q31-q32. A locus for Goltz syndrome in region 9q32-qter?" in: Human genetics, Vol. 82, Issue 1, pp. 17-9, 1989 (PubMed).

Matsuura, Igarashi, Tanizawa et al.: "Human adenylate kinase deficiency associated with hemolytic anemia. A single base substitution affecting solubility and catalytic activity of the cytosolic adenylate kinase." in: The Journal of biological chemistry, Vol. 264, Issue 17, pp. 10148-55, 1989 (PubMed).

Miwa, Fujii, Tani et al.: "Red cell adenylate kinase deficiency associated with hereditary nonspherocytic hemolytic anemia: clinical and biochemical studies." in: American journal of hematology, Vol. 14, Issue 4, pp. 325-33, 1983 (PubMed).

Toren, Brok-Simoni, Ben-Bassat et al.: "Congenital haemolytic anaemia associated with adenylate kinase deficiency." in: British journal of haematology, Vol. 87, Issue 2, pp. 376-80, 1994 (PubMed).

Corrons, Garcia, Tusell et al.: "Red cell adenylate kinase deficiency: molecular study of 3 new mutations (118G>A, 190G>A, and GAC deletion) associated with hereditary nonspherocytic hemolytic anemia." in: Blood, Vol. 102, Issue 1, pp. 353-6, 2003 (PubMed).

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