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PTPN21 antibody (AA 751-780)

PTPN21 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB0623-0624 unconjugated
Catalog No. ABIN392838
  • Target See all PTPN21 Antibodies
    PTPN21 (Protein tyrosine Phosphatase, Non-Receptor Type 21 (PTPN21))
    Binding Specificity
    • 15
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 751-780
    Reactivity
    • 28
    • 22
    • 21
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 29
    Rabbit
    Clonality
    • 29
    Polyclonal
    Conjugate
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PTPN21 antibody is un-conjugated
    Application
    • 29
    • 13
    • 13
    • 12
    • 9
    • 3
    • 3
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This PTPD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-780 amino acids from the Central region of human PTPD1.
    Clone
    RB0623-0624
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Fox, Storey: "BMX Negatively Regulates BAK Function, Thereby Increasing Apoptotic Resistance to Chemotherapeutic Drugs." in: Cancer research, Vol. 75, Issue 7, pp. 1345-55, (2015) (PubMed).

  • Target
    PTPN21 (Protein tyrosine Phosphatase, Non-Receptor Type 21 (PTPN21))
    Alternative Name
    PTPD1 (PTPN21 Products)
    Synonyms
    PTPD1 antibody, PTPRL10 antibody, Ptp2E antibody, protein tyrosine phosphatase, non-receptor type 21 antibody, PTPN21 antibody, Ptpn21 antibody
    Background
    PTPD1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.
    Molecular Weight
    133281
    Gene ID
    11099
    NCBI Accession
    NP_008970
    UniProt
    Q16825
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