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Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) (AA 1-111) antibody

Details for Product No. ABIN393204
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Antigen
Synonyms xCaspase-10, alps2, caspace-10, caspase-10, flice2, mch4, xCaspace-10, ALPS2, FLICE2, MCH4
Epitope
AA 1-111
(28), (5), (4), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(114), (16), (15), (1), (1), (1)
Host
Mouse
(104), (7), (2), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(92), (41), (23), (21), (19), (11), (10), (6), (4), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393204
450.00 $
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Immunogen CASP10 (NP_116756, 1 a.a. ~ 111 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E7
Isotype IgG2a kappa
Specificity CASP10 (NP_116756, 1 a.a. ~ 111 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CASP10
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 58951 DA
Gene ID 12406
UniProt NP_116756
Research Area Apoptosis/Necrosis, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) (AA 1-111) antibody CASP10 monoclonal antibody (M02), clone 2E7. Western Blot analysis of CASP10 expression in U-2 OS. Detection limit for recombinant GST tagged CASP10 is approximately 0.03 ng/mL as a capture antibody.
anti-Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) (AA 1-111) antibody (2) anti-Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) (AA 1-111) antibody (Image 2)
Background publications Oh, Kim, Ahn et al.: "Mutational analysis of CASP10 gene in colon, breast, lung and hepatocellular carcinomas." in: Pathology, Vol. 42, Issue 1, pp. 73-6, 2009 (PubMed).

Kim, Park, Kim et al.: "Mutational analysis of caspase genes in prostate carcinomas." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 118, Issue 4, pp. 308-12, 2010 (PubMed).

Liu, Wu, Chen et al.: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).

Ho-Pun-Cheung, Assenat, Bascoul-Mollevi et al.: "A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer." in: The pharmacogenomics journal, Vol. 11, Issue 6, pp. 437-43, 2011 (PubMed).

Lee, Choi, Choi et al.: "Polymorphisms in the caspase genes and the risk of lung cancer." in: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Vol. 5, Issue 8, pp. 1152-8, 2010 (PubMed).

Validation Images
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