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GAS2 antibody (Growth Arrest-Specific 2) (AA 1-111)

Details for Product anti-GAS2 Antibody No. ABIN393205, Supplier: Log in to see
Antigen
  • GAS2
  • gas2
  • si:packt119.1
  • GAS-2
  • Gas-2
  • RGD1563167
  • growth arrest-specific 2
  • growth arrest-specific 2b
  • growth arrest specific 2
  • GAS2
  • gas2b
  • Gas2
Alternatives
anti-Human GAS2 antibody for Immunofluorescence
Epitope
AA 1-111
17
11
7
6
5
4
2
2
1
Reactivity
Human
72
30
28
Host
Mouse
58
14
Clonality (Clone)
Monoclonal ()
Conjugate
This GAS2 antibody is un-conjugated
5
5
4
3
3
3
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
55
35
17
13
8
8
4
2
1
1
Options
Supplier
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Immunogen GAS2 (NP_005247, 1 a.a. ~ 111 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4E11
Isotype IgG2a kappa
Specificity GAS2 (NP_005247, 1 a.a. ~ 111 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name GAS2 (GAS2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 34945 DA
Gene ID 12406
NCBI Accession NP_005247
Research Area Apoptosis/Necrosis, Cell Structure
Pathways Caspase Cascade in Apoptosis
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-GAS2 antibody (Growth Arrest-Specific 2) (AA 1-111) (ABIN393205) Immunofluorescence of monoclonal antibody to GAS2 on NIH/3T3 cell (antibody concentra...
Immunohistochemistry (IHC) image for anti-GAS2 antibody (Growth Arrest-Specific 2) (AA 1-111) (ABIN393205) anti-Growth Arrest-Specific 2 (GAS2) (AA 1-111) antibody (Image 2)
Background publications Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, 2010 (PubMed).

Kimura, Wakamatsu, Suzuki, Ota, Nishikawa, Yamashita, Yamamoto, Sekine, Tsuritani, Wakaguri, Ishii, Sugiyama, Saito, Isono, Irie, Kushida, Yoneyama, Otsuka, Kanda, Yokoi, Kondo, Wagatsuma, Murakawa et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ..." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Benetti, Copetti, DellOrso, Melloni, Brancolini, Monte, Schneider: "The calpain system is involved in the constitutive regulation of beta-catenin signaling functions." in: The Journal of biological chemistry, Vol. 280, Issue 23, pp. 22070-80, 2005 (PubMed).

Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Tsutsumi, Kamata, Vokes, Maruoka, Nakakuki, Enomoto, Omura, Amagasa, Nagayama, Saito-Ohara, Inazawa, Moritani, Yamaoka, Inoue, Itakura: "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD)." in: American journal of human genetics, Vol. 74, Issue 6, pp. 1255-61, 2004 (PubMed).