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Growth Arrest-Specific 2 (GAS2) (AA 1-111) antibody

Details for Product No. ABIN393205
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Antigen
Synonyms GAS2, gas2, si:packt119.1, GAS-2, Gas-2, RGD1563167
Epitope
AA 1-111
(7), (7), (6), (3), (2), (2), (1)
Reactivity
Human
(38), (19), (18)
Host
Mouse
(27), (11)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(29), (19), (10), (8), (6), (4), (2), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN393205
450.00 $
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Immunogen GAS2 (NP_005247, 1 a.a. ~ 111 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4E11
Isotype IgG2a kappa
Specificity GAS2 (NP_005247, 1 a.a. ~ 111 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name GAS2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 34945 DA
Gene ID 12406
UniProt NP_005247
Research Area Apoptosis/Necrosis, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Growth Arrest-Specific 2 (GAS2) (AA 1-111) antibody Immunofluorescence of monoclonal antibody to GAS2 on NIH/3T3 cell (antibody concentration 10 µg/mL). GAS2 monoclonal antibody (M01), clone 4E11 Western Blot analysis of GAS2 expression in NIH/3T3.
anti-Growth Arrest-Specific 2 (GAS2) (AA 1-111) antibody (2) anti-Growth Arrest-Specific 2 (GAS2) (AA 1-111) antibody (Image 2)
Background publications Tsutsumi, Kamata, Vokes et al.: "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD)." in: American journal of human genetics, Vol. 74, Issue 6, pp. 1255-61, 2004 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Benetti, Copetti, DellOrso et al.: "The calpain system is involved in the constitutive regulation of beta-catenin signaling functions." in: The Journal of biological chemistry, Vol. 280, Issue 23, pp. 22070-80, 2005 (PubMed).

Talmud, Drenos, Shah et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Shimada, Miyagawa, Kawashima et al.: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, 2010 (PubMed).

Validation Images
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