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Caspase 10 antibody (Caspase 10, Apoptosis-Related Cysteine Peptidase) (AA 1-111)

Details for Product anti-CASP10 Antibody No. ABIN393206, Supplier: Log in to see
Antigen
  • xCaspase-10
  • alps2
  • caspace-10
  • caspase-10
  • flice2
  • mch4
  • xCaspace-10
  • ALPS2
  • FLICE2
  • MCH4
Alternatives
anti-Human Caspase 10 antibody for Western Blotting
Epitope
AA 1-111
28
8
5
5
5
4
4
4
3
3
3
3
3
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
138
20
18
1
Host
Mouse
124
8
3
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Caspase 10 antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA
110
44
32
21
19
11
8
7
3
2
2
1
1
Supplier
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Immunogen CASP10 (NP_116756, 1 a.a. ~ 111 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1D8
Isotype IgG1 kappa
Specificity CASP10 (NP_116756, 1 a.a. ~ 111 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CASP10 (CASP10 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 58951 DA
Gene ID 12406
NCBI Accession NP_116756
Research Area Apoptosis/Necrosis, Cell Structure
Pathways Apoptosis, Caspase Cascade in Apoptosis
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Caspase 10 antibody (Caspase 10, Apoptosis-Related Cysteine Peptidase) (AA 1-111) (ABIN393206) Detection limit for recombinant GST tagged CASP10 is approximately 0.03 ng/mL as a ca...
Background publications Lee, Choi, Choi et al.: "Polymorphisms in the caspase genes and the risk of lung cancer." in: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Vol. 5, Issue 8, pp. 1152-8, 2010 (PubMed).

Ho-Pun-Cheung, Assenat, Bascoul-Mollevi et al.: "A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer." in: The pharmacogenomics journal, Vol. 11, Issue 6, pp. 437-43, 2011 (PubMed).

Liu, Wu, Chen et al.: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).

Kim, Park, Kim et al.: "Mutational analysis of caspase genes in prostate carcinomas." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 118, Issue 4, pp. 308-12, 2010 (PubMed).

Oh, Kim, Ahn et al.: "Mutational analysis of CASP10 gene in colon, breast, lung and hepatocellular carcinomas." in: Pathology, Vol. 42, Issue 1, pp. 73-6, 2009 (PubMed).