Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) antibody

Details for Product No. ABIN393207
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Antigen
Synonyms CD130, CDW130, GP130, IL-6RB
Reactivity
Human
(88), (34), (13), (1)
Host
Mouse
(49), (40), (7), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(6), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(45), (45), (36), (18), (13), (11), (10), (10), (7), (6), (3), (2), (2), (1)
Pubmed 5 references available
Catalog no. ABIN393207
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Immunogen IL6ST (NP_002175, 23 a.a. ~ 123 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2A4
Isotype IgG2b kappa
Specificity IL6ST (NP_002175, 23 a.a. ~ 123 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name IL6ST
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 103523 DA
Gene ID 12406
UniProt NP_002175
Research Area Apoptosis/Necrosis, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) antibody Detection limit for recombinant GST tagged IL6ST is approximately 0.1 ng/mL as a capture antibody.
Background publications Xu, Kershaw, Luo et al.: "Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes." in: The Journal of biological chemistry, Vol. 285, Issue 28, pp. 21214-8, 2010 (PubMed).

Larsen, Hansen, Møller et al.: "Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer." in: Molecular and cellular biology, Vol. 30, Issue 17, pp. 4175-87, 2010 (PubMed).

Hilfiker-Kleiner, Shukla, Klein et al.: "Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction." in: Circulation, Vol. 122, Issue 2, pp. 145-55, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Hosts (49), (40), (7), (2), (1)
Reactivities (88), (34), (13), (1)
Applications (45), (45), (36), (18), (13), (11), (10), (10), (7), (6), (3), (2), (2), (1)
Conjugates (6), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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