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IL6ST antibody (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor)) (AA 23-123)

Details for Product anti-IL6ST Antibody No. ABIN393207, Supplier: Log in to see
Antigen
  • 5133400A03Rik
  • AA389424
  • Ac1055
  • BB405851
  • CD130
  • CDW130
  • D13Ertd699e
  • GP130
  • gp130
  • Gp130
  • IL-6RB
  • Il-6rb
Alternatives
anti-Human IL6ST antibody for Enzyme Immunoassay
Epitope
AA 23-123
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15
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8
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Reactivity
Human
146
61
30
3
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1
Host
Mouse
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32
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2
Clonality (Clone)
Monoclonal ()
Conjugate
This IL6ST antibody is un-conjugated
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Application
ELISA, Western Blotting (WB)
96
79
53
31
17
16
13
12
12
12
11
10
6
4
2
2
2
2
1
Supplier
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Immunogen IL6ST (NP_002175, 23 a.a. ~ 123 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2A4
Isotype IgG2b kappa
Specificity IL6ST (NP_002175, 23 a.a. ~ 123 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name IL6ST (IL6ST Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 103523 DA
Gene ID 12406
NCBI Accession NP_002175
Research Area Apoptosis/Necrosis, Cell Structure
Pathways JAK-STAT Signaling
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-IL6ST antibody (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor)) (AA 23-123) (ABIN393207) Detection limit for recombinant GST tagged IL6ST is approximately 0.1 ng/mL as a capt...
Background publications Johnatty, Beesley, Chen, Macgregor, Duffy, Spurdle, deFazio, Gava, Webb, Rossing, Doherty, Goodman, Lurie, Thompson, Wilkens, Ness, Moysich, Chang-Claude, Wang-Gohrke, Cramer, Terry, Hankinson, Tworoger, Garcia-Closas, Yang, Lissowska, Chanock, Pharoah, S: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Hilfiker-Kleiner, Shukla, Klein, Schaefer, Stapel, Hoch, Müller, Scherr, Theilmeier, Ernst, Hilfiker, Drexler: "Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction." in: Circulation, Vol. 122, Issue 2, pp. 145-55, 2010 (PubMed).

Larsen, Hansen, Møller, Madsen, Scheller, Nielsen, Petersen: "Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer." in: Molecular and cellular biology, Vol. 30, Issue 17, pp. 4175-87, 2010 (PubMed).

Xu, Kershaw, Luo, Soo, Pocock, Czabotar, Hilton, Nicola, Garrett, Zhang: "Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes." in: The Journal of biological chemistry, Vol. 285, Issue 28, pp. 21214-8, 2010 (PubMed).