Programmed Cell Death 6 (PDCD6) (AA 92-191) antibody

Details for Product No. ABIN393208
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Antigen
Synonyms pdcd6, MGC52821, MGC132114, zgc:63952, PDCD6, ALG-2, PEF1B, AV299538, Alg2, MA-3, PS2, alg-2
Epitope
AA 92-191
(9), (9), (8), (7), (1)
Reactivity
Human
(61), (18), (14), (11), (11), (11)
Host
Mouse
(55), (7)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(6), (6), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(40), (34), (12), (11), (9), (9), (5), (3), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393208
450.00 $
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Immunogen PDCD6 (AAH12384, 92 a.a. ~ 191 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2B4
Isotype IgG2a kappa
Specificity PDCD6 (AAH12384, 92 a.a. ~ 191 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name PDCD6
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 21868 DA
Gene ID 12406
Research Area Apoptosis/Necrosis, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Programmed Cell Death 6 (PDCD6) (AA 92-191) antibody Immunofluorescence of monoclonal antibody to PDCD6 on HeLa cell (antibody concentration 10 µg/mL). PDCD6 monoclonal antibody (M01), clone 2B4 Western Blot analysis of PDCD6 expression in HeLa.
anti-Programmed Cell Death 6 (PDCD6) (AA 92-191) antibody (2) anti-Programmed Cell Death 6 (PDCD6) (AA 92-191) antibody (Image 2)
Background publications Suzuki, Kawasaki, Inuzuka et al.: "Structural basis for Ca2+ -dependent formation of ALG-2/Alix peptide complex: Ca2+/EF3-driven arginine switch mechanism." in: Structure (London, England : 1993), Vol. 16, Issue 10, pp. 1562-73, 2008 (PubMed).

Yamada, Arao, Gotoda et al.: "Identification of prognostic biomarkers in gastric cancer using endoscopic biopsy samples." in: Cancer science, Vol. 99, Issue 11, pp. 2193-9, 2008 (PubMed).

Suzuki, Kawasaki, Kakiuchi et al.: "Crystallization and X-ray diffraction analysis of N-terminally truncated human ALG-2." in: Acta crystallographica. Section F, Structural biology and crystallization communications, Vol. 64, Issue Pt 11, pp. 974-7, 2008 (PubMed).

Okumura, Ichioka, Kobayashi et al.: "Penta-EF-hand protein ALG-2 functions as a Ca2+-dependent adaptor that bridges Alix and TSG101." in: Biochemical and biophysical research communications, Vol. 386, Issue 1, pp. 237-41, 2009 (PubMed).

Vergarajauregui, Martina, Puertollano: "Identification of the penta-EF-hand protein ALG-2 as a Ca2+-dependent interactor of mucolipin-1." in: The Journal of biological chemistry, Vol. 284, Issue 52, pp. 36357-66, 2009 (PubMed).

Validation Images
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