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Modulator of Apoptosis 1 (MOAP1) (AA 1-352) antibody

Details for Product No. ABIN393213
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Antigen
Synonyms MOAP1, MAP-1, PNMA4, AA987038, Map-1, Pnma4
Epitope
AA 1-352
(7), (6), (5), (5), (3), (2), (1)
Reactivity
Human
(33), (9), (1)
Host
Mouse
(31), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(34), (14), (4), (3), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393213
450.00 $
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Immunogen MOAP1 (AAH15044, 1 a.a. ~ 352 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4A11
Isotype IgG1 kappa
Specificity MOAP1 (AAH15044, 1 a.a. ~ 352 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MOAP1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 39513 DA
Gene ID 12406
Research Area Apoptosis/Necrosis, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Modulator of Apoptosis 1 (MOAP1) (AA 1-352) antibody Detection limit for recombinant GST tagged MOAP1 is approximately 1 ng/mL as a capture antibody.
Background publications Mehrle, Rosenfelder, Schupp et al.: "The LIFEdb database in 2006." in: Nucleic acids research, Vol. 34, Issue Database issue, pp. D415-8, 2005 (PubMed).

Lim, Hao, Shaw et al.: "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration." in: Cell, Vol. 125, Issue 4, pp. 801-14, 2006 (PubMed).

Fu, Sukumaran, Yu: "Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 24, pp. 10051-6, 2007 (PubMed).

Foley, Freedman, Choo et al.: "Dynamics of RASSF1A/MOAP-1 association with death receptors." in: Molecular and cellular biology, Vol. 28, Issue 14, pp. 4520-35, 2008 (PubMed).

Lee, Fu, Sukumaran et al.: "TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process." in: Experimental cell research, Vol. 315, Issue 7, pp. 1313-25, 2009 (PubMed).

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