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Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 23-123) antibody

Details for Product No. ABIN393214, Supplier: Log in to see
Antigen
  • 5133400A03Rik
  • AA389424
  • BB405851
  • CD130
  • D13Ertd699e
  • gp130
  • Ac1055
  • Gp130
  • Il-6rb
  • CDW130
  • GP130
  • IL-6RB
Alternatives
anti-Human Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) antibody for Enzyme Immunoassay
Epitope
AA 23-123
18
15
14
13
13
11
4
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
113
39
21
2
1
1
1
Host
Mouse
74
46
12
2
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
11
8
8
7
5
4
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
59
50
45
25
17
11
11
9
9
6
5
3
3
2
2
1
1
1
Supplier
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Immunogen IL6ST (NP_002175, 23 a.a. ~ 123 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4A4
Isotype IgG2a kappa
Specificity IL6ST (NP_002175, 23 a.a. ~ 123 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name IL6ST (IL6ST Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 103523 DA
Gene ID 12406
NCBI Accession NP_002175
Research Area Apoptosis/Necrosis, Cell Structure
Pathways JAK-STAT Signaling
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 23-123) antibody (ABIN393214) IL6ST monoclonal antibody (M02), clone 4A4. Western Blot analysis of IL6ST expression...
Background publications Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Hilfiker-Kleiner, Shukla, Klein et al.: "Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction." in: Circulation, Vol. 122, Issue 2, pp. 145-55, 2010 (PubMed).

Larsen, Hansen, Møller et al.: "Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer." in: Molecular and cellular biology, Vol. 30, Issue 17, pp. 4175-87, 2010 (PubMed).

Xu, Kershaw, Luo et al.: "Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes." in: The Journal of biological chemistry, Vol. 285, Issue 28, pp. 21214-8, 2010 (PubMed).