Second Mitochondria-Derived Activator of Caspase (DIABLO) (AA 119-218) antibody

Details for Product No. ABIN393216
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Antigen
Synonyms smac, smac3, diablo-s, 0610041G12Rik, 1700006L01Rik, AU040403, Smac, DFNA64, SMAC, DBO, XSmac
Epitope
AA 119-218
(33), (20), (11), (11), (4), (3), (3), (3), (2), (2), (1), (1), (1)
Reactivity
Human
(137), (57), (46), (15), (15), (14), (13), (2), (1)
Host
Mouse
(122), (22), (5), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(130), (48), (43), (35), (17), (16), (10), (7), (6), (5), (4), (3), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 0.05 mg
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Catalog No. ABIN393216
450.00 $
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Immunogen DIABLO (AAH11909, 119 a.a. ~ 218 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4F9
Isotype IgG2a kappa
Specificity DIABLO (AAH11909, 119 a.a. ~ 218 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Alternative Name DIABLO
Background This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein.
Synonyms: DIABLOS, FLJ10537, FLJ25049, SMAC, SMAC3 diablo homolog (Drosophila)
Molecular Weight 27131 DA
Gene ID 56616
Research Area Apoptosis/Necrosis, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein.

Restrictions For Research Use only
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Second Mitochondria-Derived Activator of Caspase (DIABLO) (AA 119-218) antibody Western Blot analysis of DIABLO expression in transfected 293T cell line by DIABLO monoclonal antibody (M02), clone 4F9. Lane 1: DIABLO transfected lysate(27.131 KDa). Lane 2: Non-transfected lysate. Detection limit for recombinant GST tagged DIABLO is approximately 0.3 ng/mL as a capture antibody.
anti-Second Mitochondria-Derived Activator of Caspase (DIABLO) (AA 119-218) antibody (2) anti-Second Mitochondria-Derived Activator of Caspase (DIABLO) (AA 119-218) antibody (Image 2)
Background publications Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Dai, Li, Shi et al.: "Survivin and Smac gene expressions but not livin are predictors of prognosis in non-small cell lung cancer patients treated with adjuvant chemotherapy following surgery." in: Japanese journal of clinical oncology, Vol. 40, Issue 4, pp. 327-35, 2010 (PubMed).

Bae, Kho, Lee et al.: "Hip2 interacts with and destabilizes Smac/DIABLO." in: Biochemical and biophysical research communications, Vol. 397, Issue 4, pp. 718-23, 2010 (PubMed).

Lu, Xu, Fan et al.: "Overexpression of Smac/DIABLO in Hep-2 cell line: possible role in potentiating the sensitivity of chemotherapeutic drugs." in: Tumori, Vol. 96, Issue 2, pp. 310-5, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Validation Images
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