|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Amino-terminal Enhancer of Split (AES) antibody
|Synonyms||GRG, ESP1, GRG5, TLE5, AES-1, AES-2, Grg, Grg5, AL024115, MGC124620, AES, MGC64216, zgc:64216, aes, MGC68432, grg, esp1, grg5, tle5, aes-1, aes-2|
Alternatives ELISA, Western Blotting (WB)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||AES (NP_001121, 2 a.a. ~ 111 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: AES1, AES2, ESP1, GRG, GRG5, TLE5 amino-terminal enhancer of split|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||AES (NP_001121, 2 a.a. ~ 111 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||21970 DA|
Background: The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Neurology, Cell Structure|
|Restrictions||For Research Use only|
Lim, Hao, Shaw et al.: "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration." in: Cell, Vol. 125, Issue 4, pp. 801-14, 2006 (PubMed).
Ewing, Chu, Elisma et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry." in: Molecular systems biology, Vol. 3, pp. 89, 2007 (PubMed).
Zhang, Chen, Jaramillo et al.: "Histone deacetylase-related protein inhibits AES-mediated neuronal cell death by direct interaction." in: Journal of neuroscience research, Vol. 86, Issue 11, pp. 2423-31, 2008 (PubMed).
Arce, Pate, Waterman: "Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression." in: BMC cancer, Vol. 9, pp. 159, 2009 (PubMed).
Zhang, Gao, Wang: "Structural and functional analysis of amino-terminal enhancer of split in androgen-receptor-driven transcription." in: The Biochemical journal, Vol. 427, Issue 3, pp. 499-511, 2010 (PubMed).
|Hosts||Rabbit (19), Goat (1)|
|Reactivities||Human (17), Mouse (Murine) (13), Rat (Rattus) (9), Cow (Bovine) (2), Dog (Canine) (1), Xenopus laevis (1), Zebrafish (1)|
|Applications||Western Blotting (WB) (20), Immunocytochemistry (ICC) (10), ELISA (8), Immunofluorescence (IF) (6), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (2)|
|Epitopes||C-Term (6), N-Term (3)|