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S100A5 antibody (S100 Calcium Binding Protein A5) (AA 1-91)

Details for Product anti-S100A5 Antibody No. ABIN393220, Supplier: Log in to see
Antigen
  • S100A5
  • S100D9
  • S100D
Epitope
AA 1-91
13
8
5
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
40
24
17
2
Host
Mouse
39
21
Clonality (Clone)
Monoclonal ()
Conjugate
This S100A5 antibody is un-conjugated
6
6
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
40
40
18
7
6
4
3
3
2
Supplier
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Immunogen S100A5 (NP_002953, 1 a.a. ~ 91 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5E1
Isotype IgG2a kappa
Specificity S100A5 (NP_002953, 1 a.a. ~ 91 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name S100A5 (S100A5 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 10744 DA
Gene ID 12406
NCBI Accession NP_002953
Research Area Neurology, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml
Comment

Background: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-S100A5 antibody (S100 Calcium Binding Protein A5) (AA 1-91) (ABIN393220) Immunoperoxidase of monoclonal antibody to S100A5 on formalin-fixed paraffin-embedded...
Background publications Potkin, Guffanti, Lakatos et al.: "Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease." in: PLoS ONE, Vol. 4, Issue 8, pp. e6501, 2009 (PubMed).

Stemmler, Nothnagel, Parwez et al.: "Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients." in: International journal of immunogenetics, Vol. 36, Issue 4, pp. 217-22, 2009 (PubMed).

Bertini, Das Gupta, Hu et al.: "Solution structure and dynamics of S100A5 in the apo and Ca2+-bound states." in: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, Vol. 14, Issue 7, pp. 1097-107, 2009 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1. ..." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Chan, Xia, Dong et al.: "Differential expression of S100 proteins in the developing human hippocampus and temporal cortex." in: Microscopy research and technique, Vol. 60, Issue 6, pp. 600-13, 2003 (PubMed).