Hypocretin (Orexin) Receptor 2 (HCRTR2) (AA 1-55) antibody

Details for Product No. ABIN393222
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms LOC100229747, LOC443181, hcrtr, OX2R, mOX2aR, mOX2bR, mOXR2
Epitope
AA 1-55
(7), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(20), (3), (3), (2)
Host
Mouse
(15), (3), (3)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB)
(18), (9), (5), (2), (2), (2), (1), (1), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
Shipping to United States (Change)
Availability Will be delivered in 8 to 11 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN393222
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen HCRTR2 (NP_001517, 1 a.a. ~ 55 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1E3
Isotype IgG1 kappa
Specificity HCRTR2 (NP_001517, 1 a.a. ~ 55 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HCRTR2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 50694 DA
Gene ID 12406
NCBI Accession NP_001517
Research Area Neurology, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Hypocretin (Orexin) Receptor 2 (HCRTR2) (AA 1-55) antibody Western Blot analysis of HCRTR2 expression in transfected 293T cell line by HCRTR2 monoclonal antibody (M01), clone 1E3. Lane 1: HCRTR2 transfected lysate(50.7 KDa). Lane 2: Non-transfected lysate. Western blot analysis of HCRTR2 over-expressed 293 cell line, cotransfected with HCRTR2 Validated Chimera RNAi used as specificity and loading control.
anti-Hypocretin (Orexin) Receptor 2 (HCRTR2) (AA 1-55) antibody (2) anti-Hypocretin (Orexin) Receptor 2 (HCRTR2) (AA 1-55) antibody (Image 2)
Background publications Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Fellay, Ge, Shianna et al.: "Common genetic variation and the control of HIV-1 in humans." in: PLoS genetics, Vol. 5, Issue 12, pp. e1000791, 2009 (PubMed).

Chen, Randeva: "Genomic organization and regulation of the human orexin (hypocretin) receptor 2 gene: identification of alternative promoters." in: The Biochemical journal, Vol. 427, Issue 3, pp. 377-90, 2010 (PubMed).

Pinheiro, Bulik, Thornton et al.: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Validation Images
Did you look for something else?
back to top