Hypocretin (Orexin) Receptor 2 (HCRTR2) antibody

Details for Product No. ABIN393222
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Synonyms OX2R, mOX2aR, mOX2bR, mOXR2, LOC100229747, LOC443181, hcrtr
(18), (3), (3), (1)
(13), (3), (2)
Clonality (Clone)
Monoclonal ()
Western Blotting (WB)
(15), (9), (5), (2), (2), (1)
Pubmed 5 references available
Catalog no. ABIN393222
Quantity 0.1 mg
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Immunogen HCRTR2 (NP_001517, 1 a.a. ~ 55 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1E3
Isotype IgG1 kappa
Specificity HCRTR2 (NP_001517, 1 a.a. ~ 55 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HCRTR2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 50694 DA
Gene ID 12406
UniProt NP_001517
Research Area Neurology, Cell Structure
Application Notes Western blot = 1:500-1000

Background: The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Hypocretin (Orexin) Receptor 2 (HCRTR2) antibody Western Blot analysis of HCRTR2 expression in transfected 293T cell line by HCRTR2 monoclonal antibody (M01), clone 1E3. Lane 1: HCRTR2 transfected lysate(50.7 KDa). Lane 2: Non-transfected lysate. Western blot analysis of HCRTR2 over-expressed 293 cell line, cotransfected with HCRTR2 Validated Chimera RNAi used as specificity and loading control.
anti-Hypocretin (Orexin) Receptor 2 (HCRTR2) antibody (2) anti-Hypocretin (Orexin) Receptor 2 (HCRTR2) antibody (Image 2)
Background publications Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Fellay, Ge, Shianna et al.: "Common genetic variation and the control of HIV-1 in humans." in: PLoS genetics, Vol. 5, Issue 12, pp. e1000791, 2009 (PubMed).

Chen, Randeva: "Genomic organization and regulation of the human orexin (hypocretin) receptor 2 gene: identification of alternative promoters." in: The Biochemical journal, Vol. 427, Issue 3, pp. 377-90, 2010 (PubMed).

Pinheiro, Bulik, Thornton et al.: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Hosts (13), (3), (2)
Reactivities (18), (3), (3), (1)
Applications (15), (9), (5), (2), (2), (1)
Epitopes (6), (1), (1), (1), (1)
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