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Calcium Channel, Voltage-Dependent, gamma Subunit 3 (CACNG3) (AA 199-298) antibody

Details for Product No. ABIN393224
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Antigen
Epitope
AA 199-298
(10), (7), (2), (2), (1), (1), (1)
Reactivity
Human
(38), (26), (25), (17), (17), (17), (17)
Host
Mouse
(38), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(26), (15), (14), (9), (3), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393224
450.00 $
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Immunogen CACNG3 (NP_006530, 199 a.a. ~ 298 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3E4
Isotype IgG1 kappa
Specificity CACNG3 (NP_006530, 199 a.a. ~ 298 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CACNG3
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 35549 DA
Gene ID 12406
UniProt NP_006530
Research Area Cell Structure, Neurology
Application Notes Western blot = 1:500-1000
Comment

Background: L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This protein is similar to the mouse stargazin protein, mutations in which have been associated with absence seizures, also known as petit-mal or spike-wave seizures. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family. This gene is a candidate gene for a familial infantile convulsive disorder with paroxysomal choreoathetosis.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Calcium Channel, Voltage-Dependent, gamma Subunit 3 (CACNG3) (AA 199-298) antibody Western Blot analysis of CACNG3 expression in transfected 293T cell line by CACNG3 monoclonal antibody (M01), clone 3E4. Lane 1: CACNG3 transfected lysate(35.5 KDa). Lane 2: Non-transfected lysate. CACNG3 monoclonal antibody (M01), clone 3E4 Western Blot analysis of CACNG3 expression in HeLa.
anti-Calcium Channel, Voltage-Dependent, gamma Subunit 3 (CACNG3) (AA 199-298) antibody (2) anti-Calcium Channel, Voltage-Dependent, gamma Subunit 3 (CACNG3) (AA 199-298) antibody (Image 2)
Background publications Yap, Murate, Kishigami et al.: "Adaptor protein complex-4 (AP-4) is expressed in the central nervous system neurons and interacts with glutamate receptor delta2." in: Molecular and cellular neurosciences, Vol. 24, Issue 2, pp. 283-95, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Everett, Chioza, Aicardi et al.: "Linkage and association analysis of CACNG3 in childhood absence epilepsy." in: European journal of human genetics : EJHG, Vol. 15, Issue 4, pp. 463-72, 2007 (PubMed).

Correia, Bassani, Brown et al.: "Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation." in: Nature neuroscience, Vol. 11, Issue 4, pp. 457-66, 2008 (PubMed).

Validation Images
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