Calcium Channel, Voltage-Dependent, gamma Subunit 3 (CACNG3) antibody

Antigen: Calcium Channel, Voltage-Dependent, gamma Subunit 3 (CACNG3)

Synonyms: Cacng2, CACNG3, DKFZp459K1027

Clonality: Monoclonal (3E4)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393224

Additional Information

Alternative name: CACNG3

Gene ID: 10368

UniProt: NP_006530

Immunogen: CACNG3 (NP_006530, 199 a.a. ~ 298 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 3E4

Description: Other names: Cacng2 calcium channel, voltage-dependent, gamma subunit 3

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: CACNG3 (NP_006530, 199 a.a. ~ 298 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 35549 DA

Comments:

Background: L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This protein is similar to the mouse stargazin protein, mutations in which have been associated with absence seizures, also known as petit-mal or spike-wave seizures. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family. This gene is a candidate gene for a familial infantile convulsive disorder with paroxysomal choreoathetosis.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Concentration: 1 mg/ml

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Structure, Neurology

Restrictions: For Research Use only

Images

Western Blot analysis of CACNG3 expression in transfected 293T cell line by CACNG3 monoclonal antibody (M01), clone 3E4. Lane 1: CACNG3 transfected lysate(35.5 KDa). Lane 2: Non-transfected lysate. CACNG3 monoclonal antibody (M01), clone 3E4 Western Blot analysis of CACNG3 expression in HeLa ( Cat # L013V1 ).

anti-Calcium Channel, Voltage-Dependent, gamma Subunit 3 (CACNG3) antibody (Image 2)

Publications

Product: Yap, Murate, Kishigami et al.: "Adaptor protein complex-4 (AP-4) is expressed in the central nervous system neurons and interacts with glutamate receptor delta2." in: Molecular and cellular neurosciences, Vol. 24, Issue 2, pp. 283-95, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Everett, Chioza, Aicardi et al.: "Linkage and association analysis of CACNG3 in childhood absence epilepsy." in: European journal of human genetics : EJHG, Vol. 15, Issue 4, pp. 463-72, 2007 (PubMed).

Correia, Bassani, Brown et al.: "Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation." in: Nature neuroscience, Vol. 11, Issue 4, pp. 457-66, 2008 (PubMed).