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CACNG3 antibody (Calcium Channel, Voltage-Dependent, gamma Subunit 3) (AA 199-298)

Details for Product anti-CACNG3 Antibody No. ABIN393224, Supplier: Log in to see
Antigen
Epitope
AA 199-298
19
15
4
3
2
2
2
1
1
Reactivity
Human
43
14
12
Host
Mouse
39
6
Clonality (Clone)
Monoclonal ()
Conjugate
This CACNG3 antibody is un-conjugated
2
2
2
2
2
2
Application
Western Blotting (WB)
41
21
6
3
2
1
1
Supplier
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Immunogen CACNG3 (NP_006530, 199 a.a. ~ 298 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3E4
Isotype IgG1 kappa
Specificity CACNG3 (NP_006530, 199 a.a. ~ 298 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CACNG3 (CACNG3 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 35549 DA
Gene ID 12406
NCBI Accession NP_006530
Research Area Cell Structure, Neurology
Application Notes Western blot = 1:500-1000
Comment

Background: L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This protein is similar to the mouse stargazin protein, mutations in which have been associated with absence seizures, also known as petit-mal or spike-wave seizures. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family. This gene is a candidate gene for a familial infantile convulsive disorder with paroxysomal choreoathetosis.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-CACNG3 antibody (Calcium Channel, Voltage-Dependent, gamma Subunit 3) (AA 199-298) (ABIN393224) Western Blot analysis of CACNG3 expression in transfected 293T cell line by CACNG3 mo...
Immunohistochemistry (IHC) image for anti-CACNG3 antibody (Calcium Channel, Voltage-Dependent, gamma Subunit 3) (AA 199-298) (ABIN393224) anti-Calcium Channel, Voltage-Dependent, gamma Subunit 3 (CACNG3) (AA 199-298) antibody (Image 2)
Background publications Correia, Bassani, Brown, Lisé, Backos, El-Husseini, Passafaro, Esteban: "Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation." in: Nature neuroscience, Vol. 11, Issue 4, pp. 457-66, 2008 (PubMed).

Everett, Chioza, Aicardi, Aschauer, Brouwer, Callenbach, Covanis, Dulac, Eeg-Olofsson, Feucht, Friis, Goutieres, Guerrini, Heils, Kjeldsen, Lehesjoki, Makoff, Nabbout, Olsson, Sander, Sirén, McKeigue, Robinson, Taske, Rees, Gardiner: "Linkage and association analysis of CACNG3 in childhood absence epilepsy." in: European journal of human genetics : EJHG, Vol. 15, Issue 4, pp. 463-72, 2007 (PubMed).

Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Yap, Murate, Kishigami, Muto, Kishida, Hashikawa, Yano: "Adaptor protein complex-4 (AP-4) is expressed in the central nervous system neurons and interacts with glutamate receptor delta2." in: Molecular and cellular neurosciences, Vol. 24, Issue 2, pp. 283-95, 2003 (PubMed).