Protocadherin alpha 5 (PCDHA5) (AA 183-290) antibody

Details for Product No. ABIN393229
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Antigen
Synonyms PCDHA5, CNR6, CNRN6, CNRS6, CRNR6, PCDH-ALPHA5, Cnr6, Crnr6, rCNRv05
Epitope
AA 183-290
(8), (6), (4), (2), (1), (1), (1)
Reactivity
Human
(36), (22), (22), (18), (17), (1)
Host
Mouse
(33), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(21), (15), (12), (10), (10), (4)
Pubmed 5 references available
Quantity 200 μL
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Catalog No. ABIN393229
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Immunogen PCDHA5 (NP_061731, 183 a.a. ~ 290 a.a) partial recombinant protein with GST tag.
Clone 1E8
Isotype IgM kappa
Specificity PCDHA5 (NP_061731, 183 a.a. ~ 290 a.a) partial recombinant protein with GST tag.
Purification Purified
Alternative Name PCDHA5
Background This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Synonyms: CNR6, CNRN6, CNRS6, CRNR6, PCDH-ALPHA5 protocadherin alpha 5
Molecular Weight 102048 DA
Gene ID 56143
NCBI Accession NP_061731
Research Area Cell Structure, Neurology
Application Notes Western blot = 1:500-1000
Comment

Background: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

Restrictions For Research Use only
Format Liquid
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Protocadherin alpha 5 (PCDHA5) (AA 183-290) antibody PCDHA5 monoclonal antibody (M01A), clone 1E8 Western Blot analysis of PCDHA5 expression in HeLa.
Background publications Wu, Zhang, Cheng et al.: "Comparative DNA sequence analysis of mouse and human protocadherin gene clusters." in: Genome research, Vol. 11, Issue 3, pp. 389-404, 2001 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Schmutz, Martin, Terry et al.: "The DNA sequence and comparative analysis of human chromosome 5. ..." in: Nature, Vol. 431, Issue 7006, pp. 268-74, 2004 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Wu, Ma, Brown et al.: "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening." in: Proteomics, Vol. 7, Issue 11, pp. 1775-85, 2007 (PubMed).

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