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Details for Product No. ABIN393231

Neurofilament, Heavy Polypeptide (NEFH) antibody

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Synonyms Nfh, NF-H, NF200, mKIAA0845, NFH
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN393231
Quantity 0.1 mg
450.00 $   Plus shipping costs $45.00
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Immunogen NEFH (NP_066554, 263 a.a. ~ 364 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E8
Isotype IgG2a kappa
Specificity NEFH (NP_066554, 263 a.a. ~ 364 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name NEFH
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 112480 DA
Gene ID 12406
UniProt NP_066554
Research Area Neurology, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Background: Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Rudrabhatla, Zheng, Amin et al.: "Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein." in: The Journal of biological chemistry, Vol. 283, Issue 39, pp. 26737-47, 2008 (PubMed).

Gregório, Sallet, Do et al.: "Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence." in: Psychiatry research, Vol. 165, Issue 1-2, pp. 1-9, 2008 (PubMed).

Guy, Shaw, Ross-Cisneros et al.: "Phosphorylated neurofilament heavy chain is a marker of neurodegeneration in Leber hereditary optic neuropathy (LHON)." in: Molecular vision, Vol. 14, pp. 2443-50, 2008 (PubMed).

Alberti, Gonzalez, Maldonado et al.: "Comparative study of CSF neurofilaments in HTLV-1-associated myelopathy/tropical spastic paraparesis and other neurological disorders." in: AIDS research and human retroviruses, Vol. 25, Issue 8, pp. 803-9, 2009 (PubMed).

Shrestha, Irvin, Taylor et al.: "A genome-wide association study of carotid atherosclerosis in HIV-infected men." in: AIDS (London, England), Vol. 24, Issue 4, pp. 583-92, 2010 (PubMed).

Alternatives for antigen "Neurofilament, Heavy Polypeptide (NEFH)", type "Antibodies"
Hosts (97), (41), (14)
Reactivities (95), (72), (54), (41), (24), (23), (11), (11), (10), (8), (8), (7), (6), (4), (3), (2), (2), (1), (1)
Applications (102), (64), (39), (38), (34), (33), (28), (18), (10), (6), (4), (1)
Conjugates (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (17), (3), (2), (1), (1), (1), (1), (1)