Growth Differentiation Factor 7 (GDF7) antibody

Antigen: Growth Differentiation Factor 7 (GDF7)

Synonyms: BMP12, gdf16-A

Clonality: Monoclonal (1A1)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN393235

Additional Information

Alternative name: GDF7

Gene ID: 151449

UniProt: NP_878248

Immunogen: GDF7 (NP_878248, 361 a.a. ~ 451 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 1A1

Description: Other names: growth differentiation factor 7

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: GDF7 (NP_878248, 361 a.a. ~ 451 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 46966 DA

Comments:

Background: This gene encodes a member of the bone morphogenetic protein (BMP) family. BMPs belong to the transforming growth factor-beta superfamily of secreted signalling molecules that regulate diverse processes in growth, repair and embryonic development. In mouse, this gene functions as an inductive signal from the roof plate required for the specification of neuronal identity in the dorsal spinal cord.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Neurology, Cell Structure

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged GDF7 is approximately 1ng/ml as a capture antibody.

Publications

Product: Butler, Dodd: "A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons." in: Neuron, Vol. 38, Issue 3, pp. 389-401, 2003 (PubMed).

Mazerbourg, Sangkuhl, Luo et al.: "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses." in: The Journal of biological chemistry, Vol. 280, Issue 37, pp. 32122-32, 2005 (PubMed).

Yeh, Lee: "Effects of cartilage-derived morphogenetic protein-3 on the expression of chondrogenic and osteoblastic markers in the pluripotent mesenchymal C3H10T1/2 cell line." in: Growth factors (Chur, Switzerland), Vol. 28, Issue 2, pp. 117-28, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Shimada, Miyagawa, Kawashima et al.: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, 2010 (PubMed).