Protocadherin alpha 6 (PCDHA6) (AA 295-371) antibody

Details for Product No. ABIN393239
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Antigen
Synonyms CNR2, CNRN2, CNRS2, CRNR2, PCDH-ALPHA6, CNR, Cnr2, Crnr2, rCNRv06, PCDHA5
Epitope
AA 295-371
(9), (8), (6), (3), (2), (1), (1)
Reactivity
Human
(40), (16), (16), (13), (1)
Host
Mouse
(30), (11)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(32), (18), (10), (7), (6), (4), (3)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393239
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Immunogen PCDHA6 (NP_061732, 295 a.a. ~ 371 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1A3
Isotype IgG2a kappa
Specificity PCDHA6 (NP_061732, 295 a.a. ~ 371 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name PCDHA6
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 103051 DA
Gene ID 12406
NCBI Accession NP_061732
Research Area Cell Structure, Neurology
Application Notes Western blot = 1:500-1000
Comment

Background: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Protocadherin alpha 6 (PCDHA6) (AA 295-371) antibody PCDHA6 monoclonal antibody (M05), clone 1A3 Western Blot analysis of PCDHA6 expression in K-562. Detection limit for recombinant GST tagged PCDHA6 is approximately 0.3 ng/mL as a capture antibody.
anti-Protocadherin alpha 6 (PCDHA6) (AA 295-371) antibody (2) anti-Protocadherin alpha 6 (PCDHA6) (AA 295-371) antibody (Image 2)
Background publications Wu, Zhang, Cheng et al.: "Comparative DNA sequence analysis of mouse and human protocadherin gene clusters." in: Genome research, Vol. 11, Issue 3, pp. 389-404, 2001 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Schmutz, Martin, Terry et al.: "The DNA sequence and comparative analysis of human chromosome 5." in: Nature, Vol. 431, Issue 7006, pp. 268-74, 2004 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Wu, Ma, Brown et al.: "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening." in: Proteomics, Vol. 7, Issue 11, pp. 1775-85, 2007 (PubMed).

Validation Images
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