Apelin antibody (APLN) (AA 1-122)

Details for Product anti-APLN Antibody No. ABIN393240, Supplier: Log in to see
Antigen
  • APLN
  • Xapelin
  • xnpep2
  • preproapelin
  • 6030430G11Rik
  • Apel
  • APEL
  • XNPEP2
  • apelin
  • apelin-like
  • apln
  • APLN
  • apln-b
  • Apln
  • LOC100625006
  • LOC100346492
Alternatives
anti-Human Apelin antibody for ELISA
Epitope
AA 1-122
17
8
7
6
5
3
2
2
2
1
1
Reactivity
Human
82
42
42
7
2
1
1
1
1
Host
Mouse
84
9
Clonality (Clone)
Monoclonal ()
Conjugate
This Apelin antibody is un-conjugated
9
5
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
59
52
28
13
7
5
4
4
2
1
1
Options
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Immunogen APLN (AAH21104.1, 1 a.a. ~ 122 a.a.) full-length recombinant protein with GST tag MW of the GST tag alone is 26 K
Clone 1A8-2A5
Isotype IgG IgA IgM Mix lambda
Specificity APLN (AAH21104.1, 1 a.a. ~ 122 a.a.) full-length recombinant protein with GST tag MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name APLN (APLN Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight NONE?! DA
Gene ID 12406
Research Area Neurology, Cell Structure
Pathways Positive Regulation of Peptide Hormone Secretion, Hormone Activity, Feeding Behaviour
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Apelin antibody (APLN) (AA 1-122) (ABIN393240) Detection limit for recombinant GST tagged APLN is approximately 0.03 ng/mL as a capt...
Background publications Meral, Tascilar, Karademir, Tanju, Cekmez, Ipcioglu, Ercin, Gocmen, Dogru: "Elevated plasma levels of apelin in children with type 1 diabetes mellitus." in: Journal of pediatric endocrinology & metabolism : JPEM, Vol. 23, Issue 5, pp. 497-502, 2010 (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Sonmez, Celebi, Erdem, Tapan, Genc, Tasci, Ercin, Dogru, Kilic, Uckaya, Yilmaz, Erbil, Kutlu: "Plasma apelin and ADMA Levels in patients with essential hypertension." in: Clinical and experimental hypertension (New York, N.Y. : 1993), Vol. 32, Issue 3, pp. 179-83, 2010 (PubMed).

Niu, Wu, Zhang, Li, Ji, Gao, Zhu: "Validation of genetic association in apelin-AGTRL1 system with hypertension in a larger Han Chinese population." in: Journal of hypertension, Vol. 28, Issue 9, pp. 1854-61, 2010 (PubMed).

Ziora, Oświecimska, Swietochowska, Ziora, Ostrowska, Stojewska, Klimacka-Nawrot, Dyduch, Błońska-Fajfrowska: "Assessment of serum apelin levels in girls with anorexia nervosa." in: The Journal of clinical endocrinology and metabolism, Vol. 95, Issue 6, pp. 2935-41, 2010 (PubMed).