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Apelin antibody (APLN) (AA 1-122)

Details for Product anti-APLN Antibody No. ABIN393240, Supplier: Log in to see
Antigen
  • 6030430G11Rik
  • Apel
  • APEL
  • APLN
  • preproapelin
  • Xapelin
  • XNPEP2
  • xnpep2
Epitope
AA 1-122
16
7
7
6
5
3
2
2
1
1
Reactivity
Human
75
32
30
4
1
Host
Mouse
77
9
Clonality (Clone)
Monoclonal ()
Conjugate
This Apelin antibody is un-conjugated
8
4
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
47
41
16
11
7
5
5
2
1
Supplier
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Immunogen APLN (AAH21104.1, 1 a.a. ~ 122 a.a.) full-length recombinant protein with GST tag MW of the GST tag alone is 26 K
Clone 1A8-2A5
Isotype IgG IgA IgM Mix lambda
Specificity APLN (AAH21104.1, 1 a.a. ~ 122 a.a.) full-length recombinant protein with GST tag MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name APLN (APLN Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight NONE?! DA
Gene ID 12406
Research Area Neurology, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Apelin antibody (APLN) (AA 1-122) (ABIN393240) Detection limit for recombinant GST tagged APLN is approximately 0.03 ng/mL as a capt...
Background publications Meral, Tascilar, Karademir, Tanju, Cekmez, Ipcioglu, Ercin, Gocmen, Dogru: "Elevated plasma levels of apelin in children with type 1 diabetes mellitus." in: Journal of pediatric endocrinology & metabolism : JPEM, Vol. 23, Issue 5, pp. 497-502, 2010

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010

Sonmez, Celebi, Erdem, Tapan, Genc, Tasci, Ercin, Dogru, Kilic, Uckaya, Yilmaz, Erbil, Kutlu: "Plasma apelin and ADMA Levels in patients with essential hypertension." in: Clinical and experimental hypertension (New York, N.Y. : 1993), Vol. 32, Issue 3, pp. 179-83, 2010

Niu, Wu, Zhang, Li, Ji, Gao, Zhu: "Validation of genetic association in apelin-AGTRL1 system with hypertension in a larger Han Chinese population." in: Journal of hypertension, Vol. 28, Issue 9, pp. 1854-61, 2010

Ziora, Oświecimska, Swietochowska, Ziora, Ostrowska, Stojewska, Klimacka-Nawrot, Dyduch, Błońska-Fajfrowska: "Assessment of serum apelin levels in girls with anorexia nervosa." in: The Journal of clinical endocrinology and metabolism, Vol. 95, Issue 6, pp. 2935-41, 2010