Apelin (APLN) antibody

Antigen: Apelin (APLN)

Synonyms: Apel, 6030430G11Rik, XNPEP2, APLN, Xapelin, xnpep2, preproapelin

Clonality: Monoclonal (1A8-2A5)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393240

Additional Information

Alternative name: APLN

Gene ID: 8862

Immunogen: APLN (AAH21104.1, 1 a.a. ~ 122 a.a.) full-length recombinant protein with GST tag MW of the GST tag alone is 26 K

Isotype: IgG IgA IgM Mix lambda

Clone: 1A8-2A5

Description: Other names: XNPEP2, apelin apelin, AGTRL1 ligand

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: APLN (AAH21104.1, 1 a.a. ~ 122 a.a.) full-length recombinant protein with GST tag MW of the GST tag alone is 26 KDa.

Molecular Weight: NONE?! DA

Comments:

Background: This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Neurology, Cell Structure

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged APLN is approximately 0.03ng/ml as a capture antibody.

Publications

Product: Ziora, Oświecimska, Swietochowska et al.: "Assessment of serum apelin levels in girls with anorexia nervosa." in: The Journal of clinical endocrinology and metabolism, Vol. 95, Issue 6, pp. 2935-41, 2010 (PubMed).

Niu, Wu, Zhang et al.: "Validation of genetic association in apelin-AGTRL1 system with hypertension in a larger Han Chinese population." in: Journal of hypertension, Vol. 28, Issue 9, pp. 1854-61, 2010 (PubMed).

Sonmez, Celebi, Erdem et al.: "Plasma apelin and ADMA Levels in patients with essential hypertension." in: Clinical and experimental hypertension (New York, N.Y. : 1993), Vol. 32, Issue 3, pp. 179-83, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Meral, Tascilar, Karademir et al.: "Elevated plasma levels of apelin in children with type 1 diabetes mellitus." in: Journal of pediatric endocrinology & metabolism : JPEM, Vol. 23, Issue 5, pp. 497-502, 2010 (PubMed).