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Unc-5 Homolog B (C. Elegans) (UNC5B) (AA 27-127) antibody

Details for Product No. ABIN393241, Supplier: Log in to see
Antigen
  • UNC5B
  • unc5h2
  • UNC5C
  • p53RDL1
  • p53rdl1
  • UNC5H2
  • 6330415E02Rik
  • A630020F16
  • D10Bwg0792e
  • Unc5h2
Epitope
AA 27-127
14
10
2
2
1
1
1
Reactivity
Human
37
17
16
2
2
1
Host
Mouse
19
14
4
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
19
19
11
3
1
1
1
1
1
Supplier
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Immunogen UNC5B (NP_734465, 27 a.a. ~ 127 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1A9
Isotype IgG1 kappa
Specificity UNC5B (NP_734465, 27 a.a. ~ 127 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name UNC5B (UNC5B Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 103638 DA
Gene ID 12406
NCBI Accession NP_734465
Research Area Neurology, Cell Structure
Pathways
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: UNC5B belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Unc-5 Homolog B (C. Elegans) (UNC5B) (AA 27-127) antibody (ABIN393241) Detection limit for recombinant GST tagged UNC5B is approximately 1 ng/mL as a captur...
Background publications Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Dakouane-Giudicelli, Duboucher, Fortemps et al.: "Characterization and expression of netrin-1 and its receptors UNC5B and DCC in human placenta." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 58, Issue 1, pp. 73-82, 2009 (PubMed).

Schubert, Denk, Mägdefrau et al.: "Role of the netrin system of repellent factors on synovial fibroblasts in rheumatoid arthritis and osteoarthritis." in: International journal of immunopathology and pharmacology, Vol. 22, Issue 3, pp. 715-22, 2009 (PubMed).

Hata, Kaibuchi, Inagaki et al.: "Unc5B associates with LARG to mediate the action of repulsive guidance molecule." in: The Journal of cell biology, Vol. 184, Issue 5, pp. 737-50, 2009 (PubMed).

Lesch, Timmesfeld, Renner et al.: "Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies." in: Journal of neural transmission (Vienna, Austria : 1996), Vol. 115, Issue 11, pp. 1573-85, 2008 (PubMed).