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Interleukin 1 Receptor Accessory Protein-Like 1 (IL1RAPL1) (AA 151-251) antibody

Details for Product No. ABIN393248, Supplier: Log in to see
Antigen
  • IL1R8
  • IL1RAPL
  • MRX10
  • MRX21
  • MRX34
  • OPHN4
  • TIGIRR-2
  • 6330532G10Rik
  • C030039N24
  • Il1rapl
Epitope
AA 151-251
2
2
2
1
1
1
Reactivity
Human
20
10
10
Host
Mouse
14
6
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
Application
ELISA, Western Blotting (WB)
16
11
5
2
2
1
1
Supplier
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Immunogen IL1RAPL1 (NP_055086, 151 a.a. ~ 251 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1C10
Isotype IgG2a kappa
Specificity IL1RAPL1 (NP_055086, 151 a.a. ~ 251 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name IL1RAPL1 (IL1RAPL1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 79969 DA
Gene ID 12406
NCBI Accession NP_055086
Research Area Neurology, Cell Structure
Pathways
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Interleukin 1 Receptor Accessory Protein-Like 1 (IL1RAPL1) (AA 151-251) antibody (ABIN393248) Detection limit for recombinant GST tagged IL1RAPL1 is approximately 0.3 ng/mL as a c...
Background publications Romero, Friel, Velez Edwards et al.: "A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)." in: American journal of obstetrics and gynecology, Vol. 203, Issue 4, pp. 361.e1-361.e30, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Piton, Gauthier, Hamdan et al.: "Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia." in: Molecular psychiatry, Vol. 16, Issue 8, pp. 867-80, 2011 (PubMed).

Romero, Velez Edwards, Kusanovic et al.: "Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes." in: American journal of obstetrics and gynecology, Vol. 202, Issue 5, pp. 431.e1-34, 2010 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).