Interleukin 1 Receptor Accessory Protein-Like 1 (IL1RAPL1) antibody

Antigen: Interleukin 1 Receptor Accessory Protein-Like 1 (IL1RAPL1)

Synonyms: Il1rapl, IL1R8, MRX34, OPHN4, IL1RAPL, TIGIRR-2, C030039N24, 6330532G10Rik

Clonality: Monoclonal (1C10)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393248

Additional Information

Alternative name: IL1RAPL1

Gene ID: 11141

UniProt: NP_055086

Immunogen: IL1RAPL1 (NP_055086, 151 a.a. ~ 251 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 1C10

Description: Other names: IL1R8, IL1RAPL, MRX34, OPHN4, TIGIRR2 interleukin 1 receptor accessory protein-like 1

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: IL1RAPL1 (NP_055086, 151 a.a. ~ 251 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 79969 DA

Comments:

Background: The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Neurology, Cell Structure

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged IL1RAPL1 is approximately 0.3ng/ml as a capture antibody.

Publications

Product: Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Romero, Velez Edwards, Kusanovic et al.: "Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes." in: American journal of obstetrics and gynecology, Vol. 202, Issue 5, pp. 431.e1-34, 2010 (PubMed).

Piton, Gauthier, Hamdan et al.: "Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia." in: Molecular psychiatry, Vol. 16, Issue 8, pp. 867-80, 2011 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Romero, Friel, Velez Edwards et al.: "A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)." in: American journal of obstetrics and gynecology, Vol. 203, Issue 4, pp. 361.e1-361.e30, 2010 (PubMed).