Potassium Inwardly-Rectifying Channel, Subfamily J, Member 10 (KCNJ10) (AA 276-380) antibody

Details for Product No. ABIN393249
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Antigen
Synonyms kir1.2, kir4.1, birk-10, MGC145926, BIR10, BIRK-1, Kir1.2, Kir4.1, BIRK-10, KCNJ13-PEN, KIR1.2, KIR4.1, SESAME
Epitope
AA 276-380
(7), (6), (3), (2), (2), (1), (1), (1)
Reactivity
Human
(33), (19), (19), (13), (13), (13), (13)
Host
Mouse
(29), (3), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(23), (12), (11), (10), (4), (3)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393249
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Immunogen KCNJ10 (NP_002232, 276 a.a. ~ 380 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1C11
Isotype IgG2a kappa
Specificity KCNJ10 (NP_002232, 276 a.a. ~ 380 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name KCNJ10
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 42508 DA
Gene ID 12406
NCBI Accession NP_002232
Research Area Neurology, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 10 (KCNJ10) (AA 276-380) antibody Detection limit for recombinant GST tagged KCNJ10 is approximately 0.03 ng/mL as a capture antibody.
Background publications Yang, Gurrola, Wu et al.: "Mutations of KCNJ10 together with mutations of SLC26A4 cause digenic nonsyndromic hearing loss associated with enlarged vestibular aqueduct syndrome." in: American journal of human genetics, Vol. 84, Issue 5, pp. 651-7, 2009 (PubMed).

Pawelczyk, Van Laer, Fransen et al.: "Analysis of gene polymorphisms associated with K ion circulation in the inner ear of patients susceptible and resistant to noise-induced hearing loss." in: Annals of human genetics, Vol. 73, Issue Pt 4, pp. 411-21, 2009 (PubMed).

Heuser, Nagelhus, Taubøll et al.: "Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy." in: Epilepsy research, Vol. 88, Issue 1, pp. 55-64, 2010 (PubMed).

Jonard, Niasme-Grare, Bonnet et al.: "Screening of SLC26A4, FOXI1 and KCNJ10 genes in unilateral hearing impairment with ipsilateral enlarged vestibular aqueduct." in: International journal of pediatric otorhinolaryngology, Vol. 74, Issue 9, pp. 1049-53, 2010 (PubMed).

Reichold, Zdebik, Lieberer et al.: "KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 32, pp. 14490-5, 2010 (PubMed).

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