Protocadherin gamma Subfamily A, 8 (PCDHGA8) (AA 357-445) antibody

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Antigen
Synonyms PCDH-GAMMA-A8, PCDHGB5, mKIAA4054
Epitope
AA 357-445
(17), (16), (3), (2), (2), (2), (1)
Reactivity
Human
(25), (1), (1)
Host
Mouse
(20), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (1)
Application
Western Blotting (WB)
(23), (15), (14), (12), (6), (3), (3), (1), (1), (1)
Pubmed 5 references available
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Quantity 0.1 mg
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Immunogen PCDHGA8 (NP_114477, 357 a.a. ~ 445 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1C11
Isotype IgG2a kappa
Specificity PCDHGA8 (NP_114477, 357 a.a. ~ 445 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name PCDHGA8 (PCDHGA8 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 101480 DA
Gene ID 12406
NCBI Accession NP_114477
Research Area Cell Structure, Neurology
Application Notes Western blot = 1:500-1000
Comment

Background: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Protocadherin gamma Subfamily A, 8 (PCDHGA8) (AA 357-445) antibody (ABIN393250) Western Blot analysis of PCDHGA8 expression in transfected 293T cell line by PCDHGA8 ...
Immunohistochemistry (IHC) image for anti-Protocadherin gamma Subfamily A, 8 (PCDHGA8) (AA 357-445) antibody (ABIN393250) anti-Protocadherin gamma Subfamily A, 8 (PCDHGA8) (AA 357-445) antibody (Image 2)
Background publications Wu, Zhang, Cheng et al.: "Comparative DNA sequence analysis of mouse and human protocadherin gene clusters." in: Genome research, Vol. 11, Issue 3, pp. 389-404, 2001 (PubMed).

Nollet, Kools, van Roy: "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members." in: Journal of molecular biology, Vol. 299, Issue 3, pp. 551-72, 2000 (PubMed).

Yagi, Takeichi: "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity." in: Genes & development, Vol. 14, Issue 10, pp. 1169-80, 2000 (PubMed).

Wu, Maniatis: "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 7, pp. 3124-9, 2000 (PubMed).

Wu, Maniatis: "A striking organization of a large family of human neural cadherin-like cell adhesion genes." in: Cell, Vol. 97, Issue 6, pp. 779-90, 1999 (PubMed).

Catalog No. ABIN393250
$450.00
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